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1 July 2006

Volume 194, Number 1
The Journal of Infectious Diseases 2006;194:38–41
© 2006 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2006/19401-0007$15.00
DOI: 10.1086/504719
BRIEF REPORT

Human Cytomegalovirus Infection Is Associated with Increased Proportions of NK Cells That Express the CD94/NKG2C Receptor in Aviremic HIV‐1–Positive Patients

Mónica Gumá,1,a

Cecilia Cabrera,3,a

Itziar Erkizia,3

Margarita Bofill,2,3

Bonaventura Clotet,3

Lidia Ruiz,3 and

Miguel López‐Botet1

1Molecular Immunopathology Unit, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, and 2Institucio Catalana de Recerca i Estudis Avancats, Barcelona, and 3IrsiCaixa Foundation and Lluita contra la SIDA Foundation, Hospital Universitari Germans Trias i Pujol, Badalona, Spain

In healthy blood donors, serological positivity for human cytomegalovirus (HCMV) is associated with an increased proportion of NK cells bearing the CD94/NKG2C NK cell receptor (NKR). The expression of the activating CD94/NKG2C NKR and of the inhibitory CD94/NKG2A NKR was studied in a cohort of 45 aviremic human immunodeficiency virus type 1 (HIV‐1)–positive patients receiving highly active antiretroviral therapy. The proportions of NKG2C+ NK cells were significantly increased in HIV‐1–positive patients ( , ), compared with those in 31 healthy individuals ( , ). Yet, the association vanished when HCMV serological status was considered in a multivariate regression model. These results support the conclusion that changes in the NKR repertoire in HIV1–positive patients are related to a concomitant HCMV infection.

Received 20 December 2005; accepted 23 February 2006; electronically published 24 May 2006.

Reprints or correspondence: Dr. Miguel López‐Botet, Molecular Immunopathology Unit, Dept. of Experimental and Health Sciences, Universitat Pompeu Fabra, Dr. Aiguader 80, 08003 Barcelona, Spain ().

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Paola Costa, Simona Sivori, Federica Bozzano, Isabella Martini, Alessandro Moretta, Lorenzo Moretta, Andrea De Maria. (2009) IFN- α -mediated increase in cytolytic activity of maturing NK cell upon exposure to HSV-infected myelomonocytes. European Journal of Immunology 39:1, 147-158
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V. T. K. Le, M. Trilling, M. Wilborn, H. Hengel, A. Zimmermann. (2008) Human cytomegalovirus interferes with signal transducer and activator of transcription (STAT) 2 protein stability and tyrosine phosphorylation. Journal of General Virology 89:10, 2416-2426
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Jeffrey Ward, Edward Barker. (2008) Role of natural killer cells in HIV pathogenesis. Current HIV/AIDS Reports 5:1, 44-50
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Jakob Michaëlsson, Brian R. Long, Christopher P. Loo, Lewis L. Lanier, Gerald Spotts, Frederick M. Hecht, and Douglas F. Nixon. (2008) Immune Reconstitution of CD56dim NK Cells in Individuals with Primary HIV‐1 Infection Treated with Interleukin‐2. The Journal of Infectious Diseases 197:1, 117-125
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Abstract-Full Text-PDF Version (493 kB)
Christopher M. Mela and Martin R. Goodier. (2007) The Contribution of Cytomegalovirus to Changes in NK Cell Receptor Expression in HIV‐1–Infected Individuals. The Journal of Infectious Diseases 195:1, 158-159
Online publication date: 1-Jan-2007.
Citation-Full Text-PDF Version (266 kB)
Monica Gumá and Miguel López‐Botet. (2007) Reply to Mela and Goodier. The Journal of Infectious Diseases 195:1, 159-160
Online publication date: 1-Jan-2007.
Citation-Full Text-PDF Version (266 kB)

  • Potential conflicts of interest: none reported.

    Financial support: Ministerio de Educación y Ciencia (grant SAF2004‐07632); European Community (grant QLRT‐2001‐01112); Instituto de Salud Carlos III, Ministry of Health (fellowship to M.G.); Fundació per a la Recerca Biomédica Germans Trias i Pujol in collaboration with the Spanish Health Department (contract FIS 04/00271 to C.C.).

  • The first 2 authors contributed equally to this work.

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