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1 July 2006

Volume 194, Number 1
The Journal of Infectious Diseases 2006;194:98–107
© 2006 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2006/19401-0015$15.00
DOI: 10.1086/504439
MAJOR ARTICLE

Secretory IgA, Salivary Peroxidase, and Catalase‐Mediated Microbicidal Activity during Hydrogen Peroxide Catabolism in Viridans Streptococci: Pathogen Coaggregation

Y. Uehara,1,4

K. Agematsu,4

K. Kikuchi,5

S. Matsuzaki,2

S. Imai,2

M. Takamoto,4

K. Sugane,4

T. Sugiura,3

Y. Konishi,3

N. Yoshino,1

S. Takeuchi,1

H. Seo,1

S. Kuramoto,1 and

M. Sugai6

Departments of 1General Medicine, 2Microbiology, and 3Clinical Laboratory Medicine, Kochi Medical School, Kohasu Oko‐cho Nankoku, 4Department of Infectious Immunology and Pediatrics, Shinshu University Graduate School of Medicine, Matsumoto, 5Department of Infectious Diseases, Tokyo Women’s Medical University, Shinjuku‐ku, Tokyo, and 6Department of Bacteriology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan

Viridans streptococci can kill methicillin‐resistant Staphylococcus aureus (MRSA) through the production of hydrogen peroxide (H2O2). However, several hundred viridans streptococci cells are necessary to kill 1 cfu of MRSA. We analyzed the potency of bactericidal and fungicidal effector molecules induced by catabolism of H2O2 in the oral cavity. Secretory IgA (SIgA) and an unidentified salivary component bound Streptococcus sanguinis, a viridans streprococcus, and MRSA into coaggregates. In these coaggregates, salivary peroxidase and the MRSA catalase produced singlet molecular oxygen (1O2) from H2O2 produced by viridans streptococci. SIgA converted 1O2 into ozone, which has potent bactericidal and fungicidal activity. We calculated that <10 cfu of Streptococcus sanguinis were necessary to kill 1 cfu of MRSA in the coaggregate. SIgA, Aspergillus niger catalase, and H2O2 in saliva killed Candida albicans, which is highly resistant to reagent H2O2. Together with indigenous bacteria and innate immunity, SIgA potentially constitutes a novel system that may sustain oral homeostasis.

Received 9 August 2005; accepted 26 January 2006; electronically published 30 May 2006.

Reprints or correspondence: Dr. Yoshio Uehara, Dept. of General Medicine, Kochi Medical School, Kohasu Oko‐cho Nankoku, 783‐8505 Japan ().

Cited by

Itzhak Brook. (2008) Cephalosporins in overcoming β-lactamase-producing bacteria and preservation of the interfering bacteria in the treatment of otitis, sinusitis and tonsillitis. Expert Review of Anti-infective Therapy 5:6, 939-950
Online publication date: 1-Jan-2008.
CrossRef

  • Presented in part: 49th Japanese Symposium on Staphylococci and Staphylococcal Infections, Tsukuba, Ibaraki, Japan, 7–8 September 2004 (abstract W3).

    Potential conflicts of interest: none reported.

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