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1 July 2006

Volume 194, Number 1
The Journal of Infectious Diseases 2006;194:95–97
© 2006 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2006/19401-0014$15.00
DOI: 10.1086/504294
BRIEF REPORT

Incidence of Guillain‐Barré Syndrome among Patients with Campylobacter Infection: A General Practice Research Database Study

Clarence C. Tam,1,2

Laura C. Rodrigues,1

Irene Petersen,3

Amir Islam,3

Andrew Hayward,3 and

Sarah J. O’Brien4

1Infectious Disease Epidemiology Unit, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, 2Environmental and Enteric Diseases Department, Health Protection Agency Centre for Infections, and 3Department of Primary Care and Population Sciences, University College, London, and 4Division of Medicine and Neuroscience, School of Medicine, University of Manchester, Salford, United Kingdom

The association between Campylobacter infection and subsequent Guillain‐Barré syndrome (GBS) has been well documented. To date, however, there exists no direct estimate of the incidence of GBS among patients with Campylobacter infection. Using the General Practice Research Database, we estimate the incidence of GBS in a cohort of patients presenting with Campylobacter enteritis to be 1.17/1000 person‐years, a rate 77 times greater than that in the general population. The probability that an individual who develops Campylobacter enteritis will also develop GBS during the subsequent 2‐month period is <2/10,000.

Received 21 December 2005; accepted 7 February 2006; electronically published 26 May 2006.

Reprints or correspondence: Dr. Clarence C. Tam, Infectious Disease Epidemiology Unit, Dept. of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel St., London WC1E 7HT, United Kingdom ().

Cited by

Y. DOORDUYN, W. VAN PELT, C. L. E. SIEZEN, F. VAN DER HORST, Y. T. H. P. VAN DUYNHOVEN, B. HOEBEE, R. JANSSEN. (2008) Novel insight in the association between salmonellosis or campylobacteriosis and chronic illness, and the role of host genetics in susceptibility to these diseases. Epidemiology and Infection 136:09,
Online publication date: 1-Oct-2008.
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V. Pordeus, M. Szyper-Kravitz, R. A. Levy, N. M. Vaz, Y. Shoenfeld. (2008) Infections and Autoimmunity: A Panorama. Clinical Reviews in Allergy & Immunology 34:3, 283-299
Online publication date: 1-Jul-2008.
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Nobuhiro Yuki. (2007) Campylobacter sialyltransferase gene polymorphism directs clinical features of Guillain–Barré syndrome. Journal of Neurochemistry 103:s1, 150-158
Online publication date: 1-Dec-2007.
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Lance B. Price, Amira Roess, Jay P. Graham, Shahida Baqar, Rocio Vailes, Kazim A. Sheikh, Ellen Silbergeld. (2007) Neurologic Symptoms and Neuropathologic Antibodies in Poultry Workers Exposed to Campylobacter jejuni. Journal of Occupational and Environmental Medicine 49:7, 748-755
Online publication date: 1-Aug-2007.
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Nobuhiro Yuki. (2007) Ganglioside mimicry and peripheral nerve disease. Muscle & Nerve 35:6, 691-711
Online publication date: 1-Jul-2007.
CrossRef

  • Potential conflicts of interest: none reported.

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