All Journals > The Journal of Infectious Diseases > 15 September 2006 > HAART during Acute HIV‐1 Infection

Article Tools

Search for Related Articles

  • By Author
  • Search In

Announcements

Science Watch logo

JID Article Named "New Hot Paper" by ScienceWatch.com

Dr. Lauri Hicks' 2007 article on pneumococcal disease has been named a "hot new paper" by Thompson Reuters' ScienceWatch.com. Read a Q&A about the article with Dr. Hicks here. 

Press Release

Unique Collaboration Charts the Migrations of a Parasite that Affected History
Researchers Sequence Louse DNA from Mummies and Propose New Model for its Development


In the News

Featured in Grist
"Another symptom of swine flu: instant amnesia" May 11, 2009
Swine Influenza Virus: Zoonotic Potential and Vaccination Strategies for the Control of Avian and Swine Influenzas
Eileen Thacker and Bruce Janke
Read the veterinary literature on swine flu and you get a strong sense of what might be called vaccination treadmill: the hog industry is literally scrambling to generate new vaccines for the rapidly evolving flu strains that sweep through CAFOs. Writing in the Journal of Infectious Diseases [PDF] in 2008, Eileen Thacker and Bruce Janke of Iowa State University paint a stark picture: “A number of genetically diverse viruses are circulating in swine herds throughout the world and are a major cause of concern to the swine industry,” they write. “Influenza virus infections in swine and poultry are potential sources of viruses for the next pandemic among humans.”

Featured in New York Times
"Fear of a Swine Flu Epidemic in 1976 Offers Some Lessons, and Concerns, Today" May 8, 2009
Anti‐Ganglioside Antibody Induction by Swine (A/NJ/1976/H1N1) and Other Influenza Vaccines: Insights into Vaccine‐Associated Guillain‐Barré Syndrome
Irving Nachamkin, Sean V. Shadomy, Anthony P. Moran, Nancy Cox, Collette Fitzgerald, Huong Ung, Adrian T. Corcoran, John K. Iskander, Lawrence B. Schonberger, and Robert T. Chen
Irving Nachamkin, a professor of pathology and laboratory medicine at the University of Pennsylvania, examined some 1976 vaccine that had been saved by a scientist in Texas. In a paper published last year in The Journal of Infectious Diseases, he and colleagues reported that mice given the vaccine made antibodies that reacted with gangliosides, which are components of nerve cells. An antibody attack on gangliosides is part of the disease mechanism of Guillain-Barré.

Featured in AFP
"Swine flu vaccine 'could be ready soon'" May 7, 2009
A Broadly Protective Vaccine against Globally Dispersed Clade 1 and Clade 2 H5N1 Influenza Viruses
Mary A. Hoelscher, Neetu Singh, Sanjay Garg, Lakshmi Jayashankar, Vic Veguilla, Aseem Pandey, Yumi Matsuoka, Jacqueline M. Katz, Ruben Donis, Suresh K. Mittal, and Suryaprakash Sambhara
The vaccine Mittal created for the bird flu worked on three different strains isolated over a seven-year period and was described in papers for the Journal of Infectious Diseases and the journal Clinical Pharmacology and Therapeutics.

Featured in Newsweek
"The Path of a Pandemic" http://www.newsweek.com/id/195692
Swine Influenza Virus: Zoonotic Potential and Vaccination Strategies for the Control of Avian and Swine Influenzas
Eileen Thacker and Bruce Janke
Last year researchers from Iowa State University in Ames warned that pigs located in industrial-scale farms were being subjected to influenza infections from farm poultry, wild birds and their human handlers. Writing in The Journal of Infectious Diseases, Eileen Thacker and Bruce Janke said, "As a result of the constantly changing genetic makeup of individual influenza viruses in pigs, the U.S. swine industry is continually scrambling to respond to the influenza viruses circulating within individual production systems."

15 September 2006

Volume 194, Number 6
The Journal of Infectious Diseases 2006;194:734–739
© 2006 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2006/19406-0003$15.00
DOI: 10.1086/503811
BRIEF REPORT

Immunological and Virological Impact of Highly Active Antiretroviral Therapy Initiated during Acute HIV‐1 Infection

Hendrik Streeck,1,2,5

Heiko Jessen,a

Galit Alter,1

Nickolas Teigen,1

Mike T. Waring,1

Arne Jessen,a

Ingrid Stahmer,4

Jan van Lunzen,4

Mathias Lichterfeld,1

Xiaojiang Gao,3

Todd M. Allen,1

Mary Carrington,3

Bruce D. Walker,1,2

Juergen K. Rockstroh,5 and

Marcus Altfeld1

1Partners AIDS Research Center, Infectious Disease Unit, and 2Howard Hughes Medical Institute, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, Massachusetts; 3Basic Research Program, Science Applications International Corporation–Frederick, Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland; 4Infectious Diseases Unit, University Medical Center Hamburg–Eppendorf, Hamburg, and 5Department of Internal Medicine, University of Bonn, Bonn, Germany

The immunological and virological impact of short‐term treatment initiated during acute human immunodeficiency virus type 1 (HIV‐1) infection was assessed prospectively in 20 subjects, 12 of whom initiated highly active antiretroviral therapy (HAART) for 24 weeks and then terminated treatment. Treatment resulted in suppression of viremia, an increase in the CD4+ T cell count, enhanced differentiation of HIV‐1–specific CD8+ T cells from effector memory to effector cells at week 24 of HAART, and significantly higher virus‐specific interferon‐γ+ CD8+ T cell responses after viral rebound (at week 48). However, despite these immunological changes, no differences in viremia or in the CD4+ T cell count were found 6 months after HAART was stopped, when treated subjects were compared with untreated subjects.

Received 21 November 2005; accepted 16 January 2006; electronically published 15 August 2006.

Reprints or correspondence: Dr. Marcus Altfeld, Partners AIDS Research Center, Massachusetts General Hospital, Bldg. 149, 13th St., 6th Floor, Charlestown, MA 02129 ().

Cited by

C. Lecuroux, I. Girault, A. Urrutia, J.-M. Doisne, C. Deveau, C. Goujard, L. Meyer, M. Sinet, A. Venet. (2009) Identification of a particular HIV-specific CD8+ T-cell subset with a CD27+ CD45RO-/RA+ phenotype and memory characteristics after initiation of HAART during acute primary HIV infection. Blood 113:14, 3209-3217
Online publication date: 2-Mar-2009.
CrossRef
David P. Wilson, Alexander Hoare, David G. Regan, Matthew G. Law. (2009) Importance of promoting HIV testing for preventing secondary transmissions: modelling the Australian HIV epidemic among men who have sex with men. Sexual Health 6:1, 19
Online publication date: 1-Feb-2009.
CrossRef
Hendrik Streeck, Heiko Jessen, Claudia Kuecherer, Bin Li, Arne B Jessen, Stephan Dupke, Axel Baumgarten, Ingrid Stahmer, Jan van Lunzen, Marcus Altfeld, Bruce D Walker, Todd M Allen. (2009) Epidemiologically linked transmission of HIV-1 illustrates the impact of host genetics on virological outcome. AIDS 23:2, 259-262
Online publication date: 1-Feb-2009.
CrossRef
Remonie Seng, Cécile Goujard, Loïc Desquilbet, Martine Sinet, Christine Rouzioux, Christiane Deveau, Faroudy Boufassa, Jean-François Delfraissy, Laurence Meyer, Alain Venet. (2008) Rapid CD4+ Cell Decrease After Transient cART Initiated During Primary HIV Infection (ANRS PRIMO and SEROCO Cohorts). JAIDS Journal of Acquired Immune Deficiency Syndromes 49:3, 251-258
Online publication date: 1-Dec-2008.
CrossRef
B. Joos, M. Fischer, H. Kuster, S. K. Pillai, J. K. Wong, J. Boni, B. Hirschel, R. Weber, A. Trkola, H. F. Gunthard, . (2008) HIV rebounds from latently infected cells, rather than from continuing low-level replication. Proceedings of the National Academy of Sciences 105:43, 16725-16730
Online publication date: 28-Nov-2008.
CrossRef
Radjin Steingrover, Katalyn Pogány, Evian Fernandez Garcia, Suzanne Jurriaans, Kees Brinkman, Hanneke Schuitemaker, Frank Miedema, Joep MA Lange, Jan M Prins. (2008) HIV-1 viral rebound dynamics after a single treatment interruption depends on time of initiation of highly active antiretroviral therapy. AIDS 22:13, 1583-1588
Online publication date: 1-Sep-2008.
CrossRef
Maryanne T. Vahey, Zhining Wang, Zhaohui Su, Martin E. Nau, Amy Krambrink, Daniel J. Skiest, David M. Margolis. (2008) CD4 + T-Cell Decline after the Interruption of Antiretroviral Therapy in ACTG A5170 Is Predicted by Differential Expression of Genes in the Ras Signaling Pathway. AIDS Research and Human Retroviruses 24:8, 1047-1066
Online publication date: 1-Sep-2008.
CrossRef
Martin S. Hirsch. (2008) Initiating Therapy: When to Start, What to Use. The Journal of Infectious Diseases 197:s3, S252-S260
Online publication date: 15-May-2008.
Abstract-Full Text-PDF Version (305 kB)
Sarah Fidler, Julie Fox, Kholoud Porter, Jonathan Weber. (2008) Primary HIV infection: to treat or not to treat?. Current Opinion in Infectious Diseases 21:1, 4-10
Online publication date: 1-Mar-2008.
CrossRef
Nicholas I Paton. (2008) Treatment interruption strategies: how great are the risks?. Current Opinion in Infectious Diseases 21:1, 25-30
Online publication date: 1-Mar-2008.
CrossRef
Dorte Lybaek, Carsten Schade Larsen. (2008) Syncope as a probable side effect to combination antiretroviral therapy initiated during primary HIV-1 infection. Sexual Health 5:1, 69
Online publication date: 1-Feb-2008.
CrossRef
Hendrik Streeck, David van Bockel, Anthony Kelleher. (2008) T-cell responses in primary HIV-1 infection. Current Opinion in HIV and AIDS 3:1, 52-59
Online publication date: 1-Feb-2008.
CrossRef
Cristina Cellerai, Susan J Little, Sabine Kinloch-de Loes. (2008) Treatment of acute HIV-1 infection: are we getting there?. Current Opinion in HIV and AIDS 3:1, 67-74
Online publication date: 1-Feb-2008.
CrossRef
Gary R. West, Amy L. Corneli, Kim Best, Katie M. Kurkjian, William Cates Jr.. (2007) Focusing HIV Prevention on Those Most Likely to Transmit the Virus. AIDS Education and Prevention 19:4, 275-288
Online publication date: 1-Sep-2007.
CrossRef
Pierre Tattevin, Christophe Camus, Cédric Arvieux, Annick Ruffault, and Christian Michelet. (2007) Multiple Organ Failure during Primary HIV Infection. Clinical Infectious Diseases 44:3, e28-e29
Online publication date: 1-Feb-2007.
Abstract-Full Text-PDF Version (46 kB)
Daniel E Kaufmann, Bruce D Walker. (2007) Treatment interruption to boost specific HIV immunity in acute infection. Current Opinion in HIV and AIDS 2:1, 21-25
Online publication date: 1-Feb-2007.
CrossRef
Sabine Kinloch–de Loes. (2006) Treatment of Acute HIV‐1 Infection: Is It Coming of Age?. The Journal of Infectious Diseases 194:6, 721-724
Online publication date: 15-Sep-2006.
Citation-Full Text-PDF Version (67 kB)

  • Financial support: Howard Hughes Medical Institute (grant to B.D.W.); the National Institutes of Health (NIH; grants RO1 AI50429 and U01 AI052403); and the German Federal Ministry of Education and Research, HIV Competence Network (grant FKZ 01KI0211 to J.v.L. and I.S.). The study on which this report was based was supported in part with federal funds from the National Cancer Institute (NCI), NIH (contract NO1‐CO‐12400). This research was supported in part by the Intramural Research Program of the Center for Cancer Research, NCI, NIH.

    Potential conflicts of interest: none reported.

    The content of this publication does not necessarily reflect the views or policies of the US Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government.

  • Private practice, Berlin, Germany.

Back to Top
Close Popup