All Journals > The Journal of Infectious Diseases > 1 June 2006 > HIV Replication Capacity and Transmission

Article Tools

Search for Related Articles

  • By Author
  • Search In

Announcements

Science Watch logo

JID Article Named "New Hot Paper" by ScienceWatch.com

Dr. Lauri Hicks' 2007 article on pneumococcal disease has been named a "hot new paper" by Thompson Reuters' ScienceWatch.com. Read a Q&A about the article with Dr. Hicks here. 

Press Release

Unique Collaboration Charts the Migrations of a Parasite that Affected History
Researchers Sequence Louse DNA from Mummies and Propose New Model for its Development


In the News

Featured in Grist
"Another symptom of swine flu: instant amnesia" May 11, 2009
Swine Influenza Virus: Zoonotic Potential and Vaccination Strategies for the Control of Avian and Swine Influenzas
Eileen Thacker and Bruce Janke
Read the veterinary literature on swine flu and you get a strong sense of what might be called vaccination treadmill: the hog industry is literally scrambling to generate new vaccines for the rapidly evolving flu strains that sweep through CAFOs. Writing in the Journal of Infectious Diseases [PDF] in 2008, Eileen Thacker and Bruce Janke of Iowa State University paint a stark picture: “A number of genetically diverse viruses are circulating in swine herds throughout the world and are a major cause of concern to the swine industry,” they write. “Influenza virus infections in swine and poultry are potential sources of viruses for the next pandemic among humans.”

Featured in New York Times
"Fear of a Swine Flu Epidemic in 1976 Offers Some Lessons, and Concerns, Today" May 8, 2009
Anti‐Ganglioside Antibody Induction by Swine (A/NJ/1976/H1N1) and Other Influenza Vaccines: Insights into Vaccine‐Associated Guillain‐Barré Syndrome
Irving Nachamkin, Sean V. Shadomy, Anthony P. Moran, Nancy Cox, Collette Fitzgerald, Huong Ung, Adrian T. Corcoran, John K. Iskander, Lawrence B. Schonberger, and Robert T. Chen
Irving Nachamkin, a professor of pathology and laboratory medicine at the University of Pennsylvania, examined some 1976 vaccine that had been saved by a scientist in Texas. In a paper published last year in The Journal of Infectious Diseases, he and colleagues reported that mice given the vaccine made antibodies that reacted with gangliosides, which are components of nerve cells. An antibody attack on gangliosides is part of the disease mechanism of Guillain-Barré.

Featured in AFP
"Swine flu vaccine 'could be ready soon'" May 7, 2009
A Broadly Protective Vaccine against Globally Dispersed Clade 1 and Clade 2 H5N1 Influenza Viruses
Mary A. Hoelscher, Neetu Singh, Sanjay Garg, Lakshmi Jayashankar, Vic Veguilla, Aseem Pandey, Yumi Matsuoka, Jacqueline M. Katz, Ruben Donis, Suresh K. Mittal, and Suryaprakash Sambhara
The vaccine Mittal created for the bird flu worked on three different strains isolated over a seven-year period and was described in papers for the Journal of Infectious Diseases and the journal Clinical Pharmacology and Therapeutics.

Featured in Newsweek
"The Path of a Pandemic" http://www.newsweek.com/id/195692
Swine Influenza Virus: Zoonotic Potential and Vaccination Strategies for the Control of Avian and Swine Influenzas
Eileen Thacker and Bruce Janke
Last year researchers from Iowa State University in Ames warned that pigs located in industrial-scale farms were being subjected to influenza infections from farm poultry, wild birds and their human handlers. Writing in The Journal of Infectious Diseases, Eileen Thacker and Bruce Janke said, "As a result of the constantly changing genetic makeup of individual influenza viruses in pigs, the U.S. swine industry is continually scrambling to respond to the influenza viruses circulating within individual production systems."

1 June 2006

Volume 193, Number 11
The Journal of Infectious Diseases 2006;193:1512–1515
© 2006 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2006/19311-0006$15.00
DOI: 10.1086/503810
BRIEF REPORT

Association between the Replication Capacity and Mother‐to‐Child Transmission of HIV‐1, in Antiretroviral Drug–Naive Malawian Women

Susan H. Eshleman,1

Yolanda Lie,3

Donald R. Hoover,4

Shu Chen,2

Sarah E. Hudelson,1

Susan A. Fiscus,5

Christos J. Petropoulos,3

Newton Kumwenda,2

Neil Parkin,3 and

Taha E. Taha2

1Department of Pathology, Johns Hopkins University School of Medicine, and 2Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland; 3Monogram Biosciences, South San Francisco, California; 4Department of Statistics and Institute for Health, Health Care Policy and Aging Research, Rutgers University, Piscataway, New Jersey; 5Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill

Replication capacity and transmission of human immunodeficiency virus (HIV)–1 in antiretroviral drug–naive Malawian women who had subtype C infection were investigated. Infant children of these women received either 1 dose of nevirapine or 1 dose of nevirapine plus 1 week of daily doses of zidovudine. PhenoSense HIV was used to determine replication capacity in 49 women whose infants were infected with HIV‐1 and in 47 women whose infants were uninfected by 6–8 weeks of age. Mean replication capacity was higher in transmitters than in nontransmitters ( ). In a multivariate model, higher replication capacity was associated with transmission (odds ratio, 1.45 for each 10% increase in replication capacity [95% confidence interval, 1.11–1.90]; P=.0063), after adjustment for maternal HIV‐1 load and other factors.

Received 9 November 2005; accepted 11 January 2006; electronically published 20 April 2006.

Reprints or correspondence: Dr. Susan Eshleman, Dept. of Pathology, The Johns Hopkins Medical Institutions, Ross Bldg. 646, 720 Rutland Ave., Baltimore, MD 21205 ().

Cited by

Chonticha Kittinunvorakoon, Mary Kate Morris, Kanchana Neeyapun, Bongkoch Jetsawang, Gertrude C. Buehring, Carl V. Hanson. (2009) Mother to child transmission of HIV-1 in a Thai population: Role of virus characteristics and maternal humoral immune response. Journal of Medical Virology 81:5, 768-778
Online publication date: 1-Jun-2009.
CrossRef
Jan Walter, Louise Kuhn, Grace M Aldrovandi. (2008) Advances in basic science understanding of mother-to-child HIV-1 transmission. Current Opinion in HIV and AIDS 3:2, 146-150
Online publication date: 1-Apr-2008.
CrossRef
Bluma G Brenner. (2007) Resistance and viral subtypes: how important are the differences and why do they occur?. Current Opinion in HIV and AIDS 2:2, 94-102
Online publication date: 1-Apr-2007.
CrossRef

  • Conflicts of interest: Y.L., C.J.P., and N.P. are employed by and are stockholders of Monogram Biosciences, which performs the PhenoSense HIV assay.

    Financial support: HIV Prevention Trials Network, sponsored by the National Institute of Allergy and Infectious Diseases, National Institute of Child Health and Human Development, National Institute on Drug Abuse, National Institute of Mental Health, and Office of AIDS Research, National Institutes of Health (NIH), Department of Health and Human Services (grants U01‐AI‐46745 and U01‐AI‐48054); NIH (grant R01‐HD042965‐01); Fogarty International Center, NIH (AIDS FIRCA award 5R03TW01199 and supplement); National Institute of Allergy and Infectious Diseases (Small Business Innovation Research grant R44 AI050321‐03A1, for development of the Monogram PhenoSense HIV Replication Capacity assay); The Doris Duke Charitable Foundation, New York; National Science Foundation Energy Information Administration (grant 02‐05116).

Back to Top
Close Popup