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1 June 2006

Volume 193, Number 11
The Journal of Infectious Diseases 2006;193:1552–1556
© 2006 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2006/19311-0012$15.00
DOI: 10.1086/503779
BRIEF REPORT

Kinetics of US28 Gene Expression during Active Human Cytomegalovirus Infection in Lung‐Transplant Recipients

Jasper M. Boomker,1,3

Erik A. M. Verschuuren,2

Marja G. L. Brinker,1,3

Lou F. M. H. de Leij,1,3

T. Hauw The,2 and

Martin C. Harmsen1,3

1Department of Pathology and Laboratory Medicine, Medical Biology Section, and 2Department of Clinical Immunology, University Medical Center Groningen, and 3Groningen University Institute for Drug Exploration, University of Groningen, Groningen, The Netherlands

Targeting viral proteins early during infection may limit exacerbation of human cytomegalovirus infection. The viral chemokine‐receptor homologue US28 interferes with leukocyte trafficking and, possibly, viral replication. Because US28 molecules are abundant on the surface of infected cells, this homologue is a potential target for antiviral therapy. To assess the relationship between US28 and disease activity, we measured, by quantitative reverse‐transcription polymerase chain reaction, the levels of US28 and immediate‐early (IE) 1 gene transcripts in the blood of lung‐transplant recipients. We found that, during primary and secondary infection, the IE1 and US28 genes have early transcription kinetics and are expressed at similar levels. This may render US28 an attractive target for antiviral therapy.

Received 28 October 2005; accepted 23 December 2005; electronically published 24 April 2006.

Reprints or correspondence: Dr. M. C. Harmsen, Dept. of Pathology and Laboratory Medicine, Medical Biology Section, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands ().

Cited by

M. P. M. Stropes, W. E. Miller. (2008) Functional analysis of human cytomegalovirus pUS28 mutants in infected cells. Journal of General Virology 89:1, 97-105
Online publication date: 1-Feb-2008.
CrossRef
Atul Humar, Deepali Kumar, Michael Gray, George Moussa, Srividhya Venkataraman, Raahul Kumar, Graham A. Tipples. (2007) A Prospective Assessment of Cytomegalovirus Immune Evasion Gene Transcription Profiles in Transplant Patients With Cytomegalovirus Infection. Transplantation 83:9, 1200-1206
Online publication date: 1-Jun-2007.
CrossRef

  • Potential conflicts of interest: none reported.

    Financial support: Groningen University Institute for Drug Exploration (grant).

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