All Journals > The Journal of Infectious Diseases > 1 June 2006 > Maternal Antibodies and Transmission of HIV‐1

Article Tools

Search for Related Articles

  • By Author
  • Search In

Announcements

Science Watch logo

JID Article Named "New Hot Paper" by ScienceWatch.com

Dr. Lauri Hicks' 2007 article on pneumococcal disease has been named a "hot new paper" by Thompson Reuters' ScienceWatch.com. Read a Q&A about the article with Dr. Hicks here. 

Press Release

Unique Collaboration Charts the Migrations of a Parasite that Affected History
Researchers Sequence Louse DNA from Mummies and Propose New Model for its Development


In the News

Featured in Grist
"Another symptom of swine flu: instant amnesia" May 11, 2009
Swine Influenza Virus: Zoonotic Potential and Vaccination Strategies for the Control of Avian and Swine Influenzas
Eileen Thacker and Bruce Janke
Read the veterinary literature on swine flu and you get a strong sense of what might be called vaccination treadmill: the hog industry is literally scrambling to generate new vaccines for the rapidly evolving flu strains that sweep through CAFOs. Writing in the Journal of Infectious Diseases [PDF] in 2008, Eileen Thacker and Bruce Janke of Iowa State University paint a stark picture: “A number of genetically diverse viruses are circulating in swine herds throughout the world and are a major cause of concern to the swine industry,” they write. “Influenza virus infections in swine and poultry are potential sources of viruses for the next pandemic among humans.”

Featured in New York Times
"Fear of a Swine Flu Epidemic in 1976 Offers Some Lessons, and Concerns, Today" May 8, 2009
Anti‐Ganglioside Antibody Induction by Swine (A/NJ/1976/H1N1) and Other Influenza Vaccines: Insights into Vaccine‐Associated Guillain‐Barré Syndrome
Irving Nachamkin, Sean V. Shadomy, Anthony P. Moran, Nancy Cox, Collette Fitzgerald, Huong Ung, Adrian T. Corcoran, John K. Iskander, Lawrence B. Schonberger, and Robert T. Chen
Irving Nachamkin, a professor of pathology and laboratory medicine at the University of Pennsylvania, examined some 1976 vaccine that had been saved by a scientist in Texas. In a paper published last year in The Journal of Infectious Diseases, he and colleagues reported that mice given the vaccine made antibodies that reacted with gangliosides, which are components of nerve cells. An antibody attack on gangliosides is part of the disease mechanism of Guillain-Barré.

Featured in AFP
"Swine flu vaccine 'could be ready soon'" May 7, 2009
A Broadly Protective Vaccine against Globally Dispersed Clade 1 and Clade 2 H5N1 Influenza Viruses
Mary A. Hoelscher, Neetu Singh, Sanjay Garg, Lakshmi Jayashankar, Vic Veguilla, Aseem Pandey, Yumi Matsuoka, Jacqueline M. Katz, Ruben Donis, Suresh K. Mittal, and Suryaprakash Sambhara
The vaccine Mittal created for the bird flu worked on three different strains isolated over a seven-year period and was described in papers for the Journal of Infectious Diseases and the journal Clinical Pharmacology and Therapeutics.

Featured in Newsweek
"The Path of a Pandemic" http://www.newsweek.com/id/195692
Swine Influenza Virus: Zoonotic Potential and Vaccination Strategies for the Control of Avian and Swine Influenzas
Eileen Thacker and Bruce Janke
Last year researchers from Iowa State University in Ames warned that pigs located in industrial-scale farms were being subjected to influenza infections from farm poultry, wild birds and their human handlers. Writing in The Journal of Infectious Diseases, Eileen Thacker and Bruce Janke said, "As a result of the constantly changing genetic makeup of individual influenza viruses in pigs, the U.S. swine industry is continually scrambling to respond to the influenza viruses circulating within individual production systems."

1 June 2006

Volume 193, Number 11
The Journal of Infectious Diseases 2006;193:1504–1511
© 2006 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2006/19311-0005$15.00
DOI: 10.1086/503778
MAJOR ARTICLE

Revisiting the Role of Neutralizing Antibodies in Mother‐to‐Child Transmission of HIV‐1

Francis Barin,1

Gonzague Jourdain,2,3,a

Sylvie Brunet,1

Nicole Ngo‐Giang‐Huong,2,3,a

Supawadee Weerawatgoompa,4,a

Warit Karnchanamayul,4,a

Surabhon Ariyadej,4,a

Rawiwan Hansudewechakul,5,a

Jullapong Achalapong,5,a

Prapap Yuthavisuthi,6,a

Chaiwat Ngampiyaskul,6,a

Sorakij Bhakeecheep,7,a

Chittaphon Hemwutthiphan,7,a

Marc Lallemant,2,a and the

Perinatal HIV Prevention Trial Group

1Université François Rabelais, Equipe Associée 3856, Centre National de Référence du VIH, Tours, and 2Institut de Recherche pour le Développement (IRD 054), Paris, France; 3Harvard School of Public Health, Boston, Massachusetts; 4Provincial Hospital, Rayong, 5Prachanukroh Provincial Hospital, Chiang Rai, 6Prapokklao Provincial Hospital, Chantaburi, and 7Provincial Hospital, Phayao, Thailand

We analyzed the association between mother‐to‐child transmission (MTCT) of human immunodeficiency virus type 1 (HIV‐1) and maternal neutralizing antibodies to heterologous primary isolates of various HIV‐1 clades, to test the hypothesis that protective antibodies are those with broad neutralizing activity. Our study sample included 90 Thai women for whom the timing of HIV‐1 transmission (in utero or intrapartum) was known. The statistical analysis included a conditional logistic‐regression model to control for both plasma viral load and duration of zidovudine prophylaxis. The higher the titer of neutralizing antibodies to a heterologous strain of the same clade, the lower the rate of MTCT of HIV‐1. More specifically, high levels of neutralizing antibodies to the MBA (CRF01_AE) strain were associated with low intrapartum transmission of HIV‐1. This suggested that such heterologous neutralizing antibodies may be involved in the natural prevention of late perinatal HIV transmission. These data are consistent with the hypothesis that the use of some antibodies might help to prevent perinatal HIV transmission, through passive immunoprophylaxis. Moreover, the study of humoral factors associated with MTCT of HIV‐1 may identify correlates of protection that should help in the design of efficient HIV/acquired immunodeficiency syndrome vaccines.

Received 24 October 2005; accepted 30 December 2005; electronically published 21 April 2006.

Reprints or correspondence: Dr. Francis Barin, Laboratoire de Virologie, CHU Bretonneau, 2 boulevard Tonnellé, 37044 Tours cedex, France ().

Cited by

Chonticha Kittinunvorakoon, Mary Kate Morris, Kanchana Neeyapun, Bongkoch Jetsawang, Gertrude C. Buehring, Carl V. Hanson. (2009) Mother to child transmission of HIV-1 in a Thai population: Role of virus characteristics and maternal humoral immune response. Journal of Medical Virology 81:5, 768-778
Online publication date: 1-Jun-2009.
CrossRef
Quentin Sattentau. (2008) Correlates of antibody-mediated protection against HIV infection. Current Opinion in HIV and AIDS 3:3, 368-374
Online publication date: 1-Jun-2008.
CrossRef
Martine Braibant, Henri Agut, Christine Rouzioux, Dominique Costagliola, Brigitte Autran, Francis Barin. (2008) Characteristics of the env Genes of HIV Type 1 Quasispecies in Long-Term Nonprogressors With Broadly Neutralizing Antibodies. JAIDS Journal of Acquired Immune Deficiency Syndromes 47:3, 274-284
Online publication date: 1-Apr-2008.
CrossRef
Dara A. Lehman, Carey Farquhar. (2007) Biological mechanisms of vertical human immunodeficiency virus (HIV-1) transmission. Reviews in Medical Virology 17:6, 381-403
Online publication date: 1-Dec-2007.
CrossRef

  • Presented in part: AIDS Vaccine 04 Meeting, Lausanne, Switzerland, 30 August–1 September 2004 (abstract 44).

    Potential conflicts of interest: none reported.

    Financial support: Ensemble contre le Sida (Sidaction); Agence Nationale de Recherches sur le Sida; Institut de Recherche pour le Développement (IRD); National Institutes of Health (grant 5 R01 HD 33326).

  • These authors are members of the Perinatal HIV Prevention Trial Group (IRD 054, Thailand).

Back to Top
Close Popup