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15 April 2006

Volume 193, Number 8
The Journal of Infectious Diseases 2006;193:1172–1177
© 2006 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2006/19308-0016$15.00
DOI: 10.1086/501365
BRIEF REPORT

Gene Expression Profiles in Hepatitis C Virus (HCV) and HIV Coinfection: Class Prediction Analyses before Treatment Predict the Outcome of Anti‐HCV Therapy among HIV‐Coinfected Persons

R. A. Lempicki,1

M. A. Polis,2

J. Yang,1

M. McLaughlin,2

C. Koratich,2

D. W. Huang,1

B. Fullmer,1

L. Wu,2

C. A. Rehm,2

H. Masur,3

H. C. Lane,2

K. E. Sherman,4

A. S. Fauci,2 and

S. Kottilil2

1Science Applications International Program (SAIC)–Frederick, Inc., National Cancer Institute–Frederick, National Institutes of Health, Frederick, and 2Laboratory of Immunoregulation, National Institute of Allergy and Infections Diseases, and 3Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland; 4University of Cincinnati, Cincinnati, Ohio

Therapy for hepatitis C virus (HCV) infection in human immunodeficiency virus (HIV)–infected patients results in modest cure rates. Gene expression patterns in peripheral blood mononuclear cells from 29 patients coinfected with HIV and HCV were used to predict virological response to therapy for HCV infection. Prediction analysis using pretherapy samples identified 79 genes that correctly classified all 10 patients who did not respond to therapy, 8 of 10 patients with a response at the end of treatment, and 7 of 9 patients with sustained virological response (86% overall). Analysis of 17 posttreatment samples identified 105 genes that correctly classified all 9 patients with response at the end of treatment and 7 of 8 patients with sustained virological response (94% overall). Failure of anti‐HCV therapy was associated with elevated expression of interferon‐stimulated genes. Gene expression patterns may provide a tool to predict anti‐HCV therapeutic response.

Received 18 January 2005; accepted 9 November 2005; electronically published 13 March 2006.

Reprints or correspondence: Dr. Shyam Kottilil, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg. 10, Rm. 11N204, 9000 Rockville Pike, Bethesda, MD 20892 ().

Cited by

Robert D. Allison, Antonios Katsounas, Deloris E. Koziol, David E. Kleiner, Harvey J. Alter, Richard A. Lempicki, Brad Wood, Jun Yang, Brandie Fullmer, Karoll J. Cortez, Michael A. Polis, and Shyam Kottilil. (2009) Association of Interleukin‐15–Induced Peripheral Immune Activation with Hepatic Stellate Cell Activation in Persons Coinfected with Hepatitis C Virus and HIV. The Journal of Infectious Diseases 200:4, 619-623
Online publication date: 15-Aug-2009.
Abstract-Full Text-PDF Version (423 kB)
Shyam Kottilil, Michael Y. Yan, Kristin N. Reitano, Xiaozhen Zhang, Richard Lempicki, Gregg Roby, Marybeth Daucher, Jun Yang, Karoll J. Cortez, Marc Ghany, Michael A. Polis, Anthony S. Fauci. (2009) Human immunodeficiency virus and hepatitis C infections induce distinct immunologic imprints in peripheral mononuclear cells. Hepatology 50:1, 34-45
Online publication date: 1-Aug-2009.
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Daniel L Suzman, Mary McLaughlin, Zonghui Hu, David E Kleiner, Brad Wood, Richard A Lempicki, JoAnn M Mican, Anthony Suffredini, Henry Masur, Michael A Polis, Shyam Kottilil. (2008) Identification of novel markers for liver fibrosis in HIV/hepatitis C virus coinfected individuals using genomics-based approach. AIDS 22:12, 1433-1439
Online publication date: 1-Aug-2008.
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Veronique Nussenblatt, Mary McLaughlin, Catherine A. Rehm, Richard A. Lempicki, Terry Brann, Jun Yang, Michael Proschan, Helene C. Highbarger, Robin L. Dewar, Tom Imamichi, Chad Koratich, Avidan U. Neumann, Henry Masur, Michael A. Polis, Shyam Kottilil. (2007) Immunodeficiency and Intrinsic IFN Resistance Are Associated with Viral Breakthrough to HCV Therapy in HIV-Coinfected Patients. AIDS Research and Human Retroviruses 23:11, 1354-1359
Online publication date: 1-Dec-2007.
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Margaret C. Shuhart. (2007) Hepatitis C and HIV coinfection. Current Hepatitis Reports 6:2, 46-53
Online publication date: 1-Jun-2007.
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Makoto Tateno, Masao Honda, Takashi Kawamura, Hiroyuki Honda, and Shuichi Kaneko. (2007) Expression Profiling of Peripheral‐Blood Mononuclear Cells from Patients with Chronic Hepatitis C Undergoing Interferon Therapy. The Journal of Infectious Diseases 195:2, 255-267
Online publication date: 15-Jan-2007.
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Lynne Wu, Shyam Kottilil, Richard Lempicki, Jun Yang, Mary McLaughlin, Zonghui Hu, Chad Koratich, Kristin N. Reitano, Catherine A. Rehm, Henry Masur, Brad Wood, David E. Kleiner, Michael A. Polis. (2006) Hepatic Histologic Response (HR) to Combination Therapy among HCV/HIV-Coinfected Individuals: Interferon Induces HR Independent of Sustained Virologic Response (SVR). AIDS Research and Human Retroviruses 22:11, 1091-1098
Online publication date: 1-Dec-2006.
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Xiao-Song He, Xuhuai Ji, Matthew B. Hale, Ramsey Cheung, Aijaz Ahmed, Yaqian Guo, Garry P. Nolan, Lawrence M. Pfeffer, Teresa L. Wright, Neil Risch, Robert Tibshirani, Harry B. Greenberg. (2006) Global transcriptional response to interferon is a determinant of HCV treatment outcome and is modified by race. Hepatology 44:2, 352-359
Online publication date: 1-Sep-2006.
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  • Potential conflicts of interest: none reported.

    Financial support: National Institutes of Health (contract CO‐12400).

    The content of this publication does not necessarily reflect the views of policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government.

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