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1 April 2006

Volume 193, Number 7
The Journal of Infectious Diseases 2006;193:905–911
© 2006 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2006/19307-0001$15.00
DOI: 10.1086/500841
MAJOR ARTICLE

The Spectrum of Genital Herpes Simplex Virus Infection in Men Attending a Sexually Transmitted Disease Clinic

James M. Sizemore, Jr.,1,a

Fred Lakeman,2

Richard Whitley,2

Annalee Hughes,1 and

Edward W. Hook III1,3

1Division of Infectious Diseases, Department of Medicine, and 2Division of Infectious Diseases, Department of Pediatrics, University of Alabama at Birmingham, and 3Jefferson County Department of Health, Birmingham, Alabama

Background.The spectrum of genital herpes (GH) has been understudied in men, especially African American men.

Methods.Consecutive men attending a sexually transmitted diseases clinic were enrolled in a study of GH epidemiology. Consenting participants answered questionnaires detailing their sexual and social activities and underwent serological testing for herpes simplex virus types 1 and 2 (HSV‐1 and ‐2) and collection of genital swabs for viral detection.

Results.Of the 516 men enrolled, 465 (90%) were African American. Antibodies to HSV‐1 were present in 315 (61%) of participants, and 233 (45%) had antibodies to HSV‐2. Factors associated with HSV‐2 infection included older age and African American race. HSV was detected in genital swabs from 52 men; 43 (82.7%) swabs were HSV‐2 positive, and 9 (17.3%) were HSV‐1 positive. The overall viral shedding rate among men ( ) with evidence of GH (HSV‐1 or HSV‐2 infection) was 21.1%, and the asymptomatic shedding rate in this same group was 5.2%. The sensitivities of culture for detection of HSV‐1 and HSV‐2 were .22 and .58, respectively, compared with that of polymerase chain reaction.

Conclusions.Genital HSV infections are common and largely unrecognized among this segment of the population. HSV‐1 infection constitutes a nontrivial proportion of GH in these men.

Received 12 July 2005; accepted 25 October 2005; electronically published 27 February 2006.

Reprints or correspondence: Dr. James M. Sizemore, Jr., University of Tennessee, Chattanooga Branch, 960 E. 3rd St., Suite 411, Chattanooga, TN 37403 ().

Cited by

MARIA F. GALLO, LEE WARNER, MAURIZIO MACALUSO, KATHERINE M. STONE, ILENE BRILL, MICHAEL E. FLEENOR, EDWARD W. HOOK, HARLAND D. AUSTIN, FRANCIS K. LEE, ANDRé J. NAHMIAS. (2008) Risk Factors for Incident Herpes Simplex Type 2 Virus Infection Among Women Attending a Sexually Transmitted Disease Clinic. Sexually Transmitted Diseases 35:7, 679-685
Online publication date: 1-Aug-2008.
CrossRef
Peter Leone, Terri Warren, Kamal Hamed, Kenneth Fife, Anna Wald. (2007) Famciclovir Reduces Viral Mucosal Shedding in HSV-Seropositive Persons. Sexually Transmitted Diseases 34:11, 900-907
Online publication date: 1-Dec-2007.
CrossRef
Edward R. Cachay, Simon D. W. Frost, Douglas D. Richman, Davey M. Smith, and Susan J. Little. (2007) Herpes Simplex Virus Type 2 Infection Does Not Influence Viral Dynamics during Early HIV‐1 Infection. The Journal of Infectious Diseases 195:9, 1270-1277
Online publication date: 1-May-2007.
Abstract-Full Text-PDF Version (471 kB)

  • Presented in part: 2005 International Society of STD Research Conference, Amsterdam, The Netherlands, 10–13 July 2005 (abstract 817).

    Potential conflicts of interest: E.W.H. and R.W. have received research support from—and E.W.H., R.W., and J.M.S. have received honoraria from—GlaxoSmithKline.

    Financial support: University of Alabama at Birmingham Sexually Transmitted Diseases Cooperative Research Center (grant 5 U19 AI38514‐07); GlaxoSmithKline.

  • Present affiliation: University of Tennessee, Chattanooga.

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