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1 April 2006

Volume 193, Number 7
The Journal of Infectious Diseases 2006;193:912–916
© 2006 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2006/19307-0002$15.00
DOI: 10.1086/500838
BRIEF REPORT

Transmission of Integrated Human Herpesvirus 6 through Stem Cell Transplantation: Implications for Laboratory Diagnosis

Duncan A. Clark,1,a

Elisabeth P. Nacheva,2

Hoe Nam Leong,1

Diana Brazma,2

Ying Ting Li,1

Edward H. F. Tsao,1

Hubertus C. E. Buyck,1

Claire E. Atkinson,1

Heather M. Lawson,1

Michael N. Potter,2 and

Paul D. Griffiths1

1Centre for Virology, Division of Infection and Immunity, and 2Department of Haematology, Royal Free and University College Medical School, London, United Kingdom

We identified a stem cell donor with chromosomally integrated human herpesvirus (HHV)–6 and monitored the recipient for HHV‐6 after transplantation. The appearance and subsequent increase in HHV‐6 load paralleled engraftment and an increase in white blood cell count. Fluorescent in situ hybridization analysis showed integrated HHV‐6 on chromosome band 17p13.3 in the donor and in the recipient after transplantation but not in the recipient before transplantation. The increase in viral load due to the genetic transmission of integrated HHV‐6 could have been misinterpreted as substantial active infection and, thus, led to the administration of toxic antiviral therapy. We suggest that the confounding influence of integration be considered in laboratory investigations associating HHV‐6 with disease.

Received 23 June 2005; accepted 2 August 2005; electronically published 22 February 2006.

Reprints or correspondence: Dr. Duncan A. Clark, Dept. of Virology, Barts and The London NHS Trust, 51‐53 Bartholomew Close, London EC1A 7BE, UK ().

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  • Presented in part: 10th International CMV/Betaherpesvirus Workshop, Williamsburg, Virginia, April 2005 (abstract 5.04).

    Potential conflicts of interest: none reported.

    Financial support: Wellcome Trust; Kay Kendall Leukemia Fund (grant to E.P.N.); National Medical Research Council of Singapore (funding to H.N.L.).

  • Present affiliation: Department of Virology, Barts and The London NHS Trust, London, United Kingdom.

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