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1 February 2006

Volume 193, Number 3
The Journal of Infectious Diseases 2006;193:422–426
© 2005 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2006/19303-0012$15.00
DOI: 10.1086/499277
MAJOR ARTICLE

High Levels of Epstein‐Barr Virus DNA in Saliva and Peripheral Blood from Ugandan Mother‐Child Pairs

Sam M. Mbulaiteye,1

Michael Walters,2

Eric A. Engels,1

Paul M. Bakaki,3

Christopher M. Ndugwa,3

Anchilla M. Owor,3

James J. Goedert,1

Denise Whitby,2 and

Robert J. Biggar1

1Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, and 2Viral Epidemiology Section, AIDS Vaccine Program, Science Applications International Corporation–Frederick, National Cancer Institute at Frederick, Frederick, Maryland; 3Makerere University Medical School and Mulago Hospital, Kampala, Uganda

In Africa, Epstein‐Barr virus (EBV) is associated with Burkitt lymphoma. We measured levels of EBV DNA in saliva and buffy coats from 233 asymptomatic Ugandan children with sickle cell disease and their mothers by quantitative real‐time polymerase chain reaction. EBV DNA was detected in saliva from 90% of the children (median [interquartile range {IQR}] level, 5.2 [4.2–6.0] log10 copies/mL of saliva) and 79% of the mothers (median [IQR] level, 4.8 [3.7–5.6] log10 copies/mL of saliva) ( ). EBV DNA was detected in buffy coats from 86% of the children (median [IQR] level, 2.5 [2.2–2.9] log10 copies/ peripheral white blood cells [PWBCs]) and 72% of the mothers (median [IQR] level, 2.7 [2.4–3.1] log10 copies/ PWBCs) ( ). Detection of EBV DNA in saliva was positively correlated with detection in buffy coats. EBV DNA was detected more frequently in saliva and buffy coats than was human herpesvirus 8 DNA. Our results indicate that EBV infection persists, with virus readily detectable in saliva and buffy coats from persons without apparent symptoms in Africa.

Received 9 June 2005; accepted 22 August 2005; electronically published 22 December 2005.

Reprints or correspondence: Dr. Sam M. Mbulaiteye, 6120 Executive Blvd., Executive Plaza S., Room 8006, Rockville, MD 20852‐7248 ().

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Online publication date: 1-Nov-2007.
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Paolo Paoli, Chiara Pratesi, Maria Teresa Bortolin. (2007) The Epstein Barr virus DNA levels as a tumor marker in EBV-associated cancers. Journal of Cancer Research and Clinical Oncology 133:11, 809-815
Online publication date: 8-Oct-2007.
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Francesca Pica, Antonio Volpi. (2007) Transmission of human herpesvirus 8: an update. Current Opinion in Infectious Diseases 20:2, 152???156
Online publication date: 1-May-2007.
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  • Presented in part: 8th International Conference on Malignancies in AIDS and Other Immunodeficiencies, Bethesda, Maryland, 29–30 April 2004 (abstract S19).

    Potential conflicts of interest: none reported.

    Financial support: National Cancer Institute, Department of Health and Human Services (contracts N02‐CP‐91027 and N01‐CO‐12400).

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