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1 January 2006

Volume 193, Number 1
The Journal of Infectious Diseases 2006;193:9–15
© 2005 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2006/19301-0004$15.00
DOI: 10.1086/498577
MAJOR ARTICLE

Effect of HIV‐1 Infection on Antimalarial Treatment Outcomes in Uganda: A Population‐Based Study

Moses R. Kamya,1

Anne F. Gasasira,1

Adoke Yeka,2

Nathan Bakyaita,2

Samuel L. Nsobya,1

Damon Francis,3

Philip J. Rosenthal,3

Grant Dorsey,3 and

Diane Havlir3

1Department of Medicine, Makerere University Medical School, and 2Ministry of Health, Kampala, Uganda; 3Department of Medicine, San Francisco General Hospital, University of California, San Francisco

Background.Human immunodeficiency virus (HIV) infection may increase the burden of malaria by increasing susceptibility to infection or by decreasing the response to antimalarial treatment. We investigated the seroprevalence rate of HIV‐1 infection and its effect on antimalarial treatment outcomes in adults and children with uncomplicated falciparum malaria in Uganda.

Methods.This retrospective study included 1965 patients 18 months old who were randomized to receive 1 of 3 antimalarial regimens at 7 sites in Uganda. HIV‐1 testing was performed using 2 enzyme‐linked immunosorbent assays and Western blot analysis of stored blood spots. The primary study outcome was clinical treatment failure at 28 days after antimalarial treatment. Molecular genotyping was used to distinguish clinical treatment failures due to new infections from those due to recrudescences.

Results.The HIV‐1 seroprevalence rate was 2.5% in 1802 patients <18 years old and 31% in 163 patients 18 years old presenting with malaria. HIV‐1 infection was associated with a >3‐fold (hazard ratio [HR], 3.28 [95% confidence interval {CI}, 1.25–8.59]) increased risk of clinical treatment failure for adults, but there was no increased risk for HIV‐1–infected children. Molecular genotyping revealed that clinical treatment failures were due to new infections (HR, 6.35 [95% CI, 1.64–24.5]) rather than to recrudescences (HR, 1.51 [95% CI, 0.27–8.58]).

Conclusions.The HIV‐1 seroprevalence rate was surprisingly high in adults presenting with malaria. This finding supports the implementation of routine HIV counseling and testing for adults with uncomplicated falciparum malaria. HIV‐1 infection increased the susceptibility to new malarial infections but did not increase the risk of recrudescences in adults.

Received 31 May 2005; accepted 27 July 2005; electronically published 18 November 2005.

Reprints or correspondence: Dr. Moses R. Kamya, Dept. of Medicine, Makerere University, P.O. Box 7072, Kampala, Uganda ().

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  • Financial support: Centers for Disease Control and Prevention/Association of Schools of Public Health cooperative agreement “Malaria Surveillance and Control in Uganda” (grants SA3569 and S1932‐21/21); Department for International Development; National Institutes of Health (grant K24‐AI51982 to D.H.).

    Potential conflicts of interest: none reported.

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