All Journals > Clinical Infectious Diseases > 1 January 2006 > Nosocomial Multiresistant E. coli

Article Tools

Search for Related Articles

  • By Author
  • Search In

Announcements

CID LISTED AMONG
“MOST INFLUENTIAL”

Clinical Infectious Diseases has been named as one of the "100 Most Influential Journals in Biology and Medicine" of the past 100 years by the Special Libraries Association. The list was compiled by the 680-plus members of SLA’s Biomedical and Life Sciences Division.

See the full list here.

Source: The DBIO 100, the 100 Most Influential Journals in Biology & Medicine over the last 100 Years

In the News

Featured in MSNBC
"Germs and flu are up; infection control is down" June 9, 2009
Trends in the Incidence of Methicillin‐Resistant Staphylococcus aureus Infection in Children’s Hospitals in the United States
Jeffrey S. Gerber, Susan E. Coffin, Sarah A. Smathers, and Theoklis E. Zaoutis
Just this week, researchers reported that the incidence of MRSA infections among children admitted to pediatric hospitals in the United States more than tripled between 2002 and 2007. Researchers at the Children’s Hospital of Philadelphia and the University of Pennsylvania found cases of MRSA jumped from 6.7 per 1,000 admissions in 2002 to 21.1 cases per 1,000 admissions in 2007, according to a study released online Monday in the journal Clinical Infectious Diseases.

Featured in Toronto Star
"Pigs, viruses and politics" May 2, 2009
Are Swine Workers in the United States at Increased Risk of Infection with Zoonotic Influenza Virus?
Kendall P. Myers, Christopher W. Olsen, Sharon F. Setterquist, Ana W. Capuano, Kelley J. Donham, Eileen L. Thacker, James A. Merchant, and Gregory C. Gray
Another study, this one published in the U.S. journal Clinical Infectious Diseases in 2006, found that workers in meat-processing plants have a greater likelihood of being infected by some version of the H1N1 flu virus than the general population (the odds of pig farmers getting the disease are significantly greater again).

Featured in Philadelphia Inquirer
"A shot in the arm for vaccines" April 19, 2009
Vaccines: Pneumococcal Vaccination of Elderly Adults: New Paradigms for Protection
Lisa A. Jackson and Edward N. Janoff
Every year, an estimated 915,000 people 65 and older get pneumonia, and 40 percent of them end up in hospitals, according to a 2004 paper in the journal Clinical Infectious Diseases. Pneumonia often kills older people, said Richard Stefanacci, a geriatrician at the University of the Sciences in Philadelphia.

1 January 2006

Volume 42, Number 1
Clinical Infectious Diseases 2006;42:37–45
© 2005 by the Infectious Diseases Society of America. All rights reserved.
1058-4838/2006/4201-0006$15.00
DOI: 10.1086/498519
MAJOR ARTICLE

Clinical and Molecular Epidemiology of Extended‐Spectrum β‐Lactamase–Producing Escherichia coli as a Cause of Nosocomial Infection or Colonization: Implications for Control

Jesús Rodríguez‐Baño,1,3

Maria D. Navarro,1

Luisa Romero,2

Miguel A. Muniain,1,3

Evelio J. Perea,2,4

Ramón Pérez‐Cano,1,3

Jose R. Hernández,4 and

Alvaro Pascual2,4

1Sección de Enfermedades Infecciosas, Servicio de Medicina Interna, and 2Servicio de Microbiología, Hospital Universitario Virgen Macarena, and 3Departamento de Medicina and 4Departamento de Microbiología, Universidad de Sevilla, Seville, Spain

Background.Extended‐spectrum β‐lactamase (ESBL)–producing members of the Enterobacteriaceae family are important nosocomial pathogens. Escherichia coli producing a specific family of ESBL (the CTX‐M enzymes) are emerging worldwide. The epidemiology of these organisms as causes of nosocomial infection is poorly understood. The aims of this study were to investigate the clinical and molecular epidemiology of nosocomial infection or colonization due to ESBL‐producing E. coli in hospitalized patients, consider the specific types of ESBLs produced, and identify the risk factors for infection and colonization with these organisms.

Methods.All patients with nosocomial colonization and/or infection due to ESBL‐producing E. coli in 2 centers (a tertiary care hospital and a geriatric care center) identified between January 2001 and May 2002 were included. A double case‐control study was performed. The clonal relatedness of the isolates was studied by repetitive extragenic palindromic–polymerase chain reaction and pulsed‐field gel electrophoresis. ESBLs were characterized by isoelectric focusing, polymerase chain reaction, and sequencing.

Results.Forty‐seven case patients were included. CTX‐M–producing E. coli were clonally unrelated and more frequently susceptible to nonoxyimino–β‐lactams. Alternately, isolates producing SHV‐ and TEM‐type ESBL were epidemic and multidrug resistant. Urinary catheterization was a risk factor for both CTX‐M–producing and SHV‐TEM–producing isolates. Previous oxyimino–β‐lactam use, diabetes, and ultimately fatal or nonfatal underlying diseases were independent risk factors for infection or colonization with CTX‐M–producing isolates, whereas previous fluoroquinolone use was associated with infection or colonization with SHV‐TEM–producing isolates.

Conclusions.The epidemiology of ESBL‐producing E. coli as a cause of nosocomial infection is complex. Sporadic CTX‐M–producing isolates coexisted with epidemic multidrug‐resistant SHV‐TEM–producing isolates. These data should be taken into account for the design of control measures.

Received 28 June 2005; accepted 23 August 2005; electronically published 29 November 2005.

Reprints or correspondence: Dr. Jesús Rodríguez‐Baño, Sección de Enfermedades Infecciosas, Hospital Universitario Virgen Macarena, Avda Dr Fedriani 3, 41071 Seville, Spain ().

Cited by

M. Ortega, F. Marco, A. Soriano, M. Almela, J. A. Martinez, A. Munoz, J. Mensa. (2009) Analysis of 4758 Escherichia coli bacteraemia episodes: predictive factors for isolation of an antibiotic-resistant strain and their impact on the outcome. Journal of Antimicrobial Chemotherapy 63:3, 568-574
Online publication date: 15-Feb-2009.
CrossRef
Anucha Apisarnthanarak, MD; Pattarachai Kiratisin, MD, PhD; Linda M. Mundy, MD. (2008) Clinical and Molecular Epidemiology of Healthcare‐Associated Infections Due to Extended‐Spectrum β‐Lactamase (ESBL)–Producing Strains of Escherichia coli and Klebsiella pneumoniae That Harbor Multiple ESBL Genes •. Infection Control and Hospital Epidemiology 29:11, 1026-1034
Online publication date: 1-Nov-2008.
Abstract-Full Text-PDF Version (349 kB)
Jesús Rodríguez-Baño, Alvaro Pascual. (2008) Clinical significance of extended-spectrum β-lactamases. Expert Review of Anti-infective Therapy 6:5, 671-683
Online publication date: 1-Nov-2008.
CrossRef
M. Prelog, M. Fille, W. Prodinger, K. Grif, A. Brunner, R. Würzner, L. B. Zimmerhackl. (2008) CTX-M-1-Related Extended-Spectrum Beta-Lactamases Producing Escherichia coli: so far a Sporadic Event in Western Austria. Infection
Online publication date: 21-Jul-2008.
CrossRef
L Linares, C. Cervera, F Cofán, D. Lizaso, F Marco, M. J Ricart, N Esforzado, F Oppenheimer, J. M Campistol, A Moreno. (2008) Risk Factors for Infection with Extended-Spectrum and AmpC β-Lactamase-Producing Gram-Negative Rods in Renal Transplantation. American Journal of Transplantation 8:5, 1000-1005
Online publication date: 1-Jun-2008.
CrossRef
R. E. Warren, G. Harvey, R. Carr, D. Ward, A. Doroshenko. (2008) Control of infections due to extended-spectrum β-lactamase-producing organisms in hospitals and the community. Clinical Microbiology and Infection 14:s1, 124-133
Online publication date: 1-Feb-2008.
CrossRef
R. Cantón, A. Novais, A. Valverde, E. Machado, L. Peixe, F. Baquero, T. M. Coque. (2008) Prevalence and spread of extended-spectrum β-lactamase-producing Enterobacteriaceae in Europe. Clinical Microbiology and Infection 14:s1, 144-153
Online publication date: 1-Feb-2008.
CrossRef
J. Rodríguez-Baño, M. D. Navarro. (2008) Extended-spectrum β-lactamases in ambulatory care: a clinical perspective. Clinical Microbiology and Infection 14:s1, 104-110
Online publication date: 1-Feb-2008.
CrossRef
Cagri Buke, MD; Laurence Armand‐Lefevre, PharmD; Isabelle Lolom, RT; Waafa Guerinot, RT; Claude Deblangy, RN; Raymond Ruimy, MD, PhD; Antoine Andremont, MD, PhD; Jean‐Christophe Lucet, MD, PhD. (2007) Epidemiology of Multidrug‐Resistant Bacteria in Patients With Long Hospital Stays •. Infection Control and Hospital Epidemiology 28:11, 1255-1260
Online publication date: 1-Nov-2007.
Abstract-Full Text-PDF Version (144 kB)
D. M. Livermore, A. Pearson. (2007) Antibiotic resistance: location, location, location. Clinical Microbiology and Infection 13:s2, 7-16
Online publication date: 1-Jul-2007.
CrossRef
L. García San Miguel, J. Cobo, A. Valverde, T. M. Coque, S. Diz, F. Grill, R. Cantón. (2007) Clinical variables associated with the isolation of Klebsiella pneumoniae expressing different extended-spectrum ?-lactamases. Clinical Microbiology and Infection 13:5, 532-538
Online publication date: 1-Jun-2007.
CrossRef
P. Hawkey, R. Finch. (2007) Tigecycline: in-vitro performance as a predictor of clinical efficacy. Clinical Microbiology and Infection 13:4, 354-362
Online publication date: 1-May-2007.
CrossRef
J. D. D. Pitout, N. Hamilton, D. L. Church, P. Nordmann, L. Poirel. (2007) Development and clinical validation of a molecular diagnostic assay to detect CTX-M-type ??lactamases in Enterobacteriaceae. Clinical Microbiology and Infection 13:3, 291-297
Online publication date: 1-Apr-2007.
CrossRef
Philippa C Matthews, Anthony R Berendt, Benjamin A Lipsky. (2007) Clinical management of diabetic foot infection: diagnostics, therapeutics and the future. Expert Review of Anti-infective Therapy 5:1, 117
CrossRef
Jesús Rodríguez‐Baño, Maria D. Navarro, Luisa Romero, Miguel A. Muniain, Marina de Cueto, María J. Ríos, José R. Hernández, and Alvaro Pascual. (2006) Bacteremia Due to Extended‐Spectrum β‐Lactamase–Producing Escherichia coli in the CTX‐M Era: A New Clinical Challenge. Clinical Infectious Diseases 43:11, 1407-1414
Online publication date: 1-Dec-2006.
Abstract-Full Text-PDF Version (178 kB)
Jesus Rodriguez‐Baño and David L. Paterson. (2006) Editorial Commentary: A Change in the Epidemiology of Infections Due to Extended‐Spectrum β‐Lactamase–Producing Organisms. Clinical Infectious Diseases 42:7, 935-937
Online publication date: 1-Apr-2006.
Citation-Full Text-PDF Version (58 kB)
Back to Top
Close Popup