All Journals > Clinical Infectious Diseases > 1 December 2005 > Metallo‐β‐Lactamases in Australia

Article Tools

Search for Related Articles

Announcements

CID LISTED AMONG
“MOST INFLUENTIAL”

Clinical Infectious Diseases has been named as one of the "100 Most Influential Journals in Biology and Medicine" of the past 100 years by the Special Libraries Association. The list was compiled by the 680-plus members of SLA’s Biomedical and Life Sciences Division.

See the full list here.

Source: The DBIO 100, the 100 Most Influential Journals in Biology & Medicine over the last 100 Years

In the News

Featured in MSNBC
"Germs and flu are up; infection control is down" June 9, 2009
Trends in the Incidence of Methicillin‐Resistant Staphylococcus aureus Infection in Children’s Hospitals in the United States
Jeffrey S. Gerber, Susan E. Coffin, Sarah A. Smathers, and Theoklis E. Zaoutis
Just this week, researchers reported that the incidence of MRSA infections among children admitted to pediatric hospitals in the United States more than tripled between 2002 and 2007. Researchers at the Children’s Hospital of Philadelphia and the University of Pennsylvania found cases of MRSA jumped from 6.7 per 1,000 admissions in 2002 to 21.1 cases per 1,000 admissions in 2007, according to a study released online Monday in the journal Clinical Infectious Diseases.

Featured in Toronto Star
"Pigs, viruses and politics" May 2, 2009
Are Swine Workers in the United States at Increased Risk of Infection with Zoonotic Influenza Virus?
Kendall P. Myers, Christopher W. Olsen, Sharon F. Setterquist, Ana W. Capuano, Kelley J. Donham, Eileen L. Thacker, James A. Merchant, and Gregory C. Gray
Another study, this one published in the U.S. journal Clinical Infectious Diseases in 2006, found that workers in meat-processing plants have a greater likelihood of being infected by some version of the H1N1 flu virus than the general population (the odds of pig farmers getting the disease are significantly greater again).

Featured in Philadelphia Inquirer
"A shot in the arm for vaccines" April 19, 2009
Vaccines: Pneumococcal Vaccination of Elderly Adults: New Paradigms for Protection
Lisa A. Jackson and Edward N. Janoff
Every year, an estimated 915,000 people 65 and older get pneumonia, and 40 percent of them end up in hospitals, according to a 2004 paper in the journal Clinical Infectious Diseases. Pneumonia often kills older people, said Richard Stefanacci, a geriatrician at the University of the Sciences in Philadelphia.

1 December 2005

Volume 41, Number 11
Clinical Infectious Diseases 2005;41:1549–1556
© 2005 by the Infectious Diseases Society of America. All rights reserved.
1058-4838/2005/4111-0001$15.00
DOI: 10.1086/497831
MAJOR ARTICLE

Dissemination of the Metallo‐β‐Lactamase Gene blaIMP‐4 among Gram‐Negative Pathogens in a Clinical Setting in Australia

Anton Y. Peleg,1

Clare Franklin,1

Jan M. Bell,2 and

Denis W. Spelman1

1Infectious Diseases and Microbiology Department, The Alfred Hospital, Melbourne, and 2Microbiology and Infectious Diseases Department, Women’s and Children’s Hospital, Adelaide, Australia

Background.The clinical utility of carbapenems is under threat because of the emergence of acquired metallo‐β‐lactamase (MBL) genes. We describe the first outbreak in Australia of infection and/or colonization with gram‐negative pathogens carrying the MBL gene blaIMP‐4.

Methods.MBL‐producing organisms were identified using susceptibility data in conjunction with MBL screening methods. PCR and sequence analysis were performed to characterize the resistance gene and identify the presence of integrons. DNA profiles were determined by ribotyping. Clinical and epidemiological data were prospectively collected from January–July 2004.

Results.A total of 19 isolates were recovered from 16 patients: Serratia marcescens (10 isolates), Klebsiella pneumoniae (4 isolates), Pseudomonas aeruginosa (3 isolates), Escherichia coli (1 isolate), and Enterobacter cloacae (1 isolate). Isolates were resistant to most β‐lactams except aztreonam, and variable resistance to carbapenems was observed (MIC range, 2 to >8 mg/L). PCR and sequence analysis identified the blaIMP‐4 gene and a class 1 integrase (IntI1) in all isolates. Of the 16 patients, 12 (75%) had infection; 5 had septicemia, 5 had ventilator‐associated pneumonia, 1 had a urinary tract infection, and 1 had a superficial central venous line infection. Six (38%) of the 16 patients died, and 5 of those 6 (31% of the group of 16) had clinical infection with an MBL‐producing organism. All except 2 patients had spatio‐temporal epidemiological links in the intensive care unit. All K. pneumoniae isolates were of different ribogroups, whereas the S. marcescens and P. aeruginosa isolates were predominately of the same ribogroup.

Conclusions.MBL‐producing gram‐negative organisms have now emerged in Australia. The resistance gene, blaIMP‐4, appears highly mobile; this outbreak involved 5 different gram‐negative genera from patients with close epidemiological links.

Received 20 April 2005; accepted 29 July 2005; electronically published 31 October 2005.

  • (See the editorial commentary by Rossolini on pages 1557–8)

Reprints or correspondence: Dr. Anton Y. Peleg, Infectious Diseases Unit, The Alfred Hospital, Commercial Rd., Prahran 3181, Victoria, Australia ().

Cited by

Li-rong Chen, Hong-wei Zhou, Jia-chang Cai, Rong Zhang, Gong-xiang Chen. (2009) Detection of plasmid-mediated IMP-1 metallo-β-lactamase and quinolone resistance determinants in an ertapenem-resistant Enterobacter cloacae isolate. Journal of Zhejiang University SCIENCE B 10:5, 348-354
Online publication date: 1-Jun-2009.
CrossRef
R. Uma Karthika, R. Srinivasa Rao, S. Sahoo, P. Shashikala, R. Kanungo, S. Jayachandran, K. Prashanth. (2009) Phenotypic and genotypic assays for detecting the prevalence of metallo- -lactamases in clinical isolates of Acinetobacter baumannii from a South Indian tertiary care hospital. Journal of Medical Microbiology 58:4, 430-435
Online publication date: 1-May-2009.
CrossRef
Helen W. Boucher, George H. Talbot, John S. Bradley, John E. Edwards, Jr, David Gilbert, Louis B. Rice, Michael Scheld, Brad Spellberg, and John Bartlett. (2009) Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America. Clinical Infectious Diseases 48:1, 1-12
Online publication date: 1-Jan-2009.
Abstract-Full Text-PDF Version (324 kB)
Johann DD Pitout. (2008) Multiresistant Enterobacteriaceae: new threat of an old problem. Expert Review of Anti-infective Therapy 6:5, 657-669
Online publication date: 1-Nov-2008.
CrossRef
Maria Souli, Flora V. Kontopidou, Evangelos Papadomichelakis, Irene Galani, Apostolos Armaganidis, and Helen Giamarellou. (2008) Clinical Experience of Serious Infections Caused by Enterobacteriaceae Producing VIM‐1 Metallo–β‐Lactamase in a Greek University Hospital. Clinical Infectious Diseases 46:6, 847-854
Online publication date: 15-Mar-2008.
Abstract-Full Text-PDF Version (299 kB)
Varsha Gupta. (2008) Metallo beta lactamases in Pseudomonas aeruginosa and Acinetobacter species. Expert Opinion on Investigational Drugs 17:2, 131-143
Online publication date: 1-Mar-2008.
CrossRef
M. Tato, T. M. Coque, P. Ruíz‐Garbajosa, V. Pintado, J. Cobo, H. S. Sader, R. N. Jones, F. Baquero, and R. Cantón. (2007) Complex Clonal and Plasmid Epidemiology in the First Outbreak of Enterobacteriaceae Infection Involving VIM‐1 Metallo‐β‐Lactamase in Spain: Toward Endemicity?. Clinical Infectious Diseases 45:9, 1171-1178
Online publication date: 1-Nov-2007.
Abstract-Full Text-PDF Version (355 kB)
David L. Paterson and Yohei Doi. (2007) Editorial Commentary: A Step Closer to Extreme Drug Resistance (XDR) in Gram‐Negative Bacilli. Clinical Infectious Diseases 45:9, 1179-1181
Online publication date: 1-Nov-2007.
Citation-Full Text-PDF Version (195 kB)
Mariana Castanheira, Hélio S. Sader, Ronald N. Jones, Eugenio Debbia, Renata C. Picão, Ana C. Gales. (2007) In71, an Enterobacter cloacae blaVIM-1 -Carrying Integron Related to In70.2 from Italian Pseudomonas aeruginosa Isolates: A SENTRY Antimicrobial Surveillance Program Report. Microbial Drug Resistance 13:2, 130-134
Online publication date: 1-Jul-2007.
CrossRef
Frédéric Bert, Dominique Vanjak, Véronique Leflon‐Guibout, Serge Mrejen, Sandrine Delpierre, Aimée Redondo, and Marie‐Hélène Nicolas‐Chanoine. (2007) IMP‐4–Producing Pseudomonas aeruginosa in a French Patient Repatriated from Malaysia: Impact of Early Detection and Control Measures. Clinical Infectious Diseases 44:5, 764-765
Online publication date: 1-Mar-2007.
Citation-Full Text-PDF Version (169 kB)
Sophie Herbert, MBChB, BSc, MRCP; Dag S. Halvorsen, MD, MPH; Tim Leong, FJFICM; Clare Franklin, BSc; Glenys Harrington, RN, RM; Denis Spelman, FRACP, FRCPA, MPH. (2007) Large Outbreak of Infection and Colonization with Gram‐Negative Pathogens Carrying the Metallo‐β‐Lactamase Gene blaIMP‐4 at a 320‐Bed Tertiary Hospital in Australia •. Infection Control and Hospital Epidemiology 28:1, 98-101
Online publication date: 1-Jan-2007.
Abstract-Full Text-PDF Version (200 kB)
Pauline Macheboeuf, Carlos Contreras-Martel, Viviana Job, Otto Dideberg, Andrea Dessen. (2006) Penicillin Binding Proteins: key players in bacterial cell cycle and drug resistance processes. FEMS Microbiology Reviews 30:5, 673-691
Online publication date: 1-Oct-2006.
CrossRef
Gian Maria Rossolini. (2005) Editorial Commentary: Acquired Metallo‐β‐Lactamases: An Increasing Clinical Threat. Clinical Infectious Diseases 41:11, 1557-1558
Online publication date: 1-Dec-2005.
Citation-Full Text-PDF Version (56 kB)
Back to Top
Close Popup