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1 December 2005

Volume 192, Number 11
The Journal of Infectious Diseases 2005;192:1908–1911
© 2005 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2005/19211-0008$15.00
DOI: 10.1086/497606
BRIEF REPORT

The Granzyme B Inhibitor SERPINB9 (Protease Inhibitor 9) Circulates in Blood and Increases on Primary Cytomegalovirus Infection after Renal Transplantation

Ajda T. Rowshani,1

Merel C. M. Strik,4

Rosalie Molenaar,3

Si‐La Yong,3

Angela M. Wolbink,4

Frederike J. Bemelman,2

C. Erik Hack,4,5 and

Ineke J. M. ten Berge1,2

Divisions of 1Clinical Immunology and Rheumatology and 2Nephrology, Department of Internal Medicine, and 3Department of Experimental Immunology, Academic Medical Center, 4Department of Immunopathology, Sanquin Research at the Central Laboratory Bloodbank, and 5Department of Clinical Chemistry, Free University Medical Center, Amsterdam, The Netherlands

SERPINB9 is the only known human intracellular inhibitor of granzyme B (GrB), the effector molecule in immunity against cytomegalovirus (CMV) and in renal allograft rejection. Therefore, using specific enzyme‐linked immunosorbent assays, we addressed the presence of circulating SERPINB9 during primary CMV infection, subclinical rejection, acute rejection, and uncomplicated posttransplantation course. Soluble (s) SERPINB9 circulates in blood and increases on primary CMV infection. This increase was significantly higher in symptomatic than in asymptomatic patients. In contrast, sSERPINB9 levels did not change in response to subclinical or acute rejection. We demonstrated the presence of circulating sSERPINB9/sGrB complexes, which suggests that SERPINB9 has extracellular functions as well.

Received 6 March 2005; accepted 20 June 2005; electronically published 18 October 2005.

Reprints or correspondence: Dr. Ajda T. Rowshani, Academic Medical Center, University of Amsterdam, Div. of Clinical Immunology and Rheumatology, Dept. of Internal Medicine, PO Box 22700, 1100 DE Amsterdam, The Netherlands ().

Cited by

B Kircher, P Schumacher, D Nachbaur. (2009) Granzymes A and B serum levels in allo-SCT. Bone Marrow Transplantation 43:10, 787-791
Online publication date: 1-Jun-2009.
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M. S. J. Mangan, D. Kaiserman, P. I. Bird. (2008) The role of serpins in vertebrate immunity. Tissue Antigens 72:1, 1-10
Online publication date: 1-Aug-2008.
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Dipanjan Chowdhury, Judy Lieberman. (2008) Death by a Thousand Cuts: Granzyme Pathways of Programmed Cell Death. Annual Review of Immunology 26:1, 389-420
Online publication date: 1-May-2008.
CrossRef
Marguerite S. Buzza, Phillip I. Bird. (2006) Extracellular granzymes: current perspectives. Biological Chemistry 387:7, 827-837
Online publication date: 1-Aug-2006.
CrossRef

  • Potential conflicts of interest: none reported.

    Financial support: Academic Medical Center, University of Amsterdam.

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