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15 November 2005

Volume 41, Number 10
Clinical Infectious Diseases 2005;41:1531–1534
1058-4838/2005/4110-0023$15.00
DOI: 10.1086/497272
BRIEF REPORT

Bacterial Interference for Prevention of Urinary Tract Infection: A Prospective, Randomized, Placebo‐Controlled, Double‐Blind Pilot Trial

Rabih O. Darouiche,1,3

John I. Thornby,1,3

Colleen Cerra‐Stewart,1

William H. Donovan,2 and

Richard A. Hull3

1Michael E. Debakey Veterans Affairs Medical Center, 2Institute for Rehabilitation and Research, and 3Baylor College of Medicine, Houston, Texas

This prospective, randomized, placebo‐controlled, double‐blind pilot trial examined the efficacy of bacterial interference in preventing urinary tract infection (UTI) in 27 patients with spinal cord injury. Patients whose bladders became colonized with Escherichia coli 83972 were half as likely ( ) than noncolonized patients to develop UTI during the subsequent year.

Received 17 May 2005; accepted 6 July 2005; electronically published 13 October 2005.

  • (See the editorial commentary by Ronald on pages 1535–6)

Reprints or correspondence: Dr. Rabih O. Darouiche, Center for Prostheses Infection, Baylor College of Medicine, 1333 Moursund Ave., Ste. A221, Houston, TX 77030 ().

Cited by

A Prasad, M E Cevallos, S Riosa, R O Darouiche, B W Trautner. (2009) A bacterial interference strategy for prevention of UTI in persons practicing intermittent catheterization. Spinal Cord 47:7, 565-569
Online publication date: 1-Aug-2009.
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Lee E Morrow. (2009) Probiotics in the intensive care unit. Current Opinion in Critical Care 15:2, 144-148
Online publication date: 1-May-2009.
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T A Schlager, J R Johnson, L M Ouellette, T S Whittam. (2008) Escherichia coli colonizing the neurogenic bladder are similar to widespread clones causing disease in patients with normal bladder function. Spinal Cord 46:9, 633-638
Online publication date: 1-Oct-2008.
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Barbara W. Trautner, Manuel E. Cevallos, Huaiguang Li, Sarah Riosa, Richard A. Hull, Sheila I. Hull, David J. Tweardy, and Rabih O. Darouiche. (2008) Increased Expression of Type‐1 Fimbriae by Nonpathogenic Escherichia coli 83972 Results in an Increased Capacity for Catheter Adherence and Bacterial Interference. The Journal of Infectious Diseases 198:6, 899-906
Online publication date: 15-Sep-2008.
David R P Guay. (2008) Contemporary Management of Uncomplicated Urinary Tract Infections. Drugs 68:9, 1169-1205
Online publication date: 1-Feb-2008.
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Dietmar H. Borchert, Elizabeth Sheridan, Athanasios Papatsoris, Faruquz Zaman, Jayanta Barua, Islam Junaid, Jhumur Pati, Noor Buchholz, Francis Chinegwundoh. (2007) THE CASE FOR PROBIOTICS IN UROLOGY. BJU International 0:0, 071106220754001-???
Online publication date: 6-Dec-2007.
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Barbara W. Trautner, MD; Richard A. Hull, PhD; John I. Thornby, PhD; Rabih O. Darouiche, MD. (2007) Coating Urinary Catheters with an Avirulent Strain of Escherichia coli as a Means to Establish Asymptomatic Colonization •. Infection Control and Hospital Epidemiology 28:1, 92-94
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Göran Bergsten, Björn Wullt, Mark A. Schembri, Irene Leijonhufvud, Catharina Svanborg. (2007) Do type 1 fimbriae promote inflammation in the human urinary tract?. Cellular Microbiology 0:0, 070313074112002
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Gregor Reid, Andrew W. Bruce. (2006) Probiotics to prevent urinary tract infections: the rationale and evidence. World Journal of Urology 24:1, 28-32
Online publication date: 1-Mar-2006.
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Allan R. Ronald. (2005) Editorial Commentary: Bacterial Interference in the Urinary Tract. Clinical Infectious Diseases 41:10, 1535-1536
Online publication date: 15-Nov-2005.
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