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15 November 2005

Volume 192, Number 10
The Journal of Infectious Diseases 2005;192:1851–1857
© 2005 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2005/19210-0027$15.00
DOI: 10.1086/497167
MAJOR ARTICLE

Influence of the Factor V Leiden Mutation on Infectious Disease Susceptibility and Outcome: A Population‐Based Study

Thomas L. Benfield,1

Mortens Dahl,4

Børge G. Nordestgaard,3,4 and

Anne Tybjærg‐Hansen2,3

Departments of 1Infectious Diseases and 2Clinical Biochemistry, Copenhagen University Hospital, and 3The Copenhagen City Heart Study, Bispebjerg University Hospital, Copenhagen, and 4Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark

Background.The effect of the coagulation factor V Leiden mutation on infectious disease susceptibility and outcome is controversial.

Methods.We genotyped 9253 individuals from the Copenhagen City Heart Study for the factor V Leiden mutation. The risk of hospitalization for any infectious disease during a follow‐up period of 7.2 years and subsequent risk of disease progression to death were estimated by Cox proportional‐hazards regression analysis.

Results.During 66,789 person‐years of follow‐up, 1093 persons were hospitalized because of infection. The risk of urinary‐tract infection was decreased in factor V Leiden heterozygotes, compared with that in noncarriers (adjusted relative risk [aRR], 0.55 [95% confidence interval {CI}, 0.31–0.99]), whereas the risk of skin infection was increased (aRR, 1.68 [95% CI, 1.07–2.66]). No associations between carrier status and risk of diarrheal disease, other viral infections, parasitic infections, pneumonia, sepsis, or upper respiratory‐tract infection were detected. However, in subjects hospitalized for sepsis, factor V Leiden carriers were at an increased risk of mortality 28 days after admission, compared with noncarriers (aRR, 4.41; 95% CI, 1.42–13.67]).

Conclusion.In the Danish general population, the factor V Leiden mutation may be associated with infectious disease susceptibility and an increased risk of mortality from sepsis.

Received 6 April 2005; accepted 8 June 2005; electronically published 12 October 2005.

Reprints or correspondence: Dr. Thomas Benfield, Copenhagen HIV Programme, Hvidovre University Hospital, DK‐2650 Hvidovre, Denmark ().

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Massimo Franchini, Pier Mannuccio Mannucci. (2008) The hemostatic balance revisited through the lessons of mankind evolution. Internal and Emergency Medicine 3:1, 3-8
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T. Benfield, J. S. Jensen, B. G. Nordestgaard. (2007) Influence of diabetes and hyperglycaemia on infectious disease hospitalisation and outcome. Diabetologia 50:3, 549-554
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Robert I. Parker. (2006) Factor V Leiden and sepsis: Proof positive or phenomenology?*. Critical Care Medicine 34:8, 2254-2255
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Lois W. Br??ggemann, Saskia H. H. F. Schoenmakers, Angelique P. Groot, Pieter H. Reitsma, C Arnold Spek. (2006) Role of the factor V Leiden mutation in septic peritonitis assessed in factor V Leiden transgenic mice*. Critical Care Medicine 34:8, 2201-2206
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  • Potential conflicts of interest: none reported.

    Financial support: Danish Medical Association Research Fund; Danish Hospital Foundation for Medical Research; Region of Copenhagen, the Faroe Islands and Greenland; Copenhagen Hospital Corporation Research Fund.

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