A Prospective Assessment of Valganciclovir for the Treatment of Cytomegalovirus Infection and Disease in Transplant Recipients
Division of Infectious Diseases and Multi‐Organ Transplant Program, University of Toronto, Toronto, Canada
We assessed valganciclovir for the treatment of cytomegalovirus (CMV) in organ‐transplant recipients. Virologic and clinical outcomes were compared with those in matched historical control individuals. Thirty‐two patients (23 with symptomatic disease) received valganciclovir, and 32 patients received intravenous (iv) ganciclovir. The rate of virologic clearance by day 21 of therapy was similar in the valganciclovir arm (50.0%) and the ganciclovir arm (46.9%) (P value not significant). The change from baseline viral load by day 7 and day 14 of therapy was similar in both arms. Two patients treated with valganciclovir required a switch to iv ganciclovir, because of a lack of response. Valganciclovir is useful for the treatment of CMV infection and disease in selected organ‐transplant recipients.
Received 24 March 2005; accepted 28 April 2005; electronically published 23 August 2005.
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Presented in part: American Transplant Congress meeting, Washington, DC, 22–25 May 2005 (abstract 902).
Potential conflicts of interest: A.H. has received research support and honoraria from Roche Pharmaceuticals. No other author has a conflict of interest to declare.
Financial support: Roche Pharmaceuticals.





