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1 October 2005

Volume 192, Number 7
The Journal of Infectious Diseases 2005;192:1154–1157
0022-1899/2005/19207-0005$15.00
DOI: 10.1086/444398
BRIEF REPORT

A Prospective Assessment of Valganciclovir for the Treatment of Cytomegalovirus Infection and Disease in Transplant Recipients

Atul Humar,

Deborah Siegal,

George Moussa, and

Deepali Kumar

Division of Infectious Diseases and Multi‐Organ Transplant Program, University of Toronto, Toronto, Canada

We assessed valganciclovir for the treatment of cytomegalovirus (CMV) in organ‐transplant recipients. Virologic and clinical outcomes were compared with those in matched historical control individuals. Thirty‐two patients (23 with symptomatic disease) received valganciclovir, and 32 patients received intravenous (iv) ganciclovir. The rate of virologic clearance by day 21 of therapy was similar in the valganciclovir arm (50.0%) and the ganciclovir arm (46.9%) (P value not significant). The change from baseline viral load by day 7 and day 14 of therapy was similar in both arms. Two patients treated with valganciclovir required a switch to iv ganciclovir, because of a lack of response. Valganciclovir is useful for the treatment of CMV infection and disease in selected organ‐transplant recipients.

Received 24 March 2005; accepted 28 April 2005; electronically published 23 August 2005.

Reprints or correspondence: Dr. Atul Humar, Dept. of Medicine, Div. of Infectious Diseases and Multi‐Organ Transplant Program, Toronto General Hospital–University Health Network, 585 University Ave., NCSB 11C‐1232, Toronto, Ontario, Canada, M5G 2C4 ().

Cited by

Raymund Rabe Razonable. (2009) Management of Cytomegalovirus Infection After Renal Transplantation. Infectious Diseases in Clinical Practice 17:4, 220-230
Online publication date: 1-Aug-2009.
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David A Pegues. (2008) Utility of oral valganciclovir for the treatment of cytomegalovirus disease after renal transplantation. Nature Clinical Practice Nephrology 4:1, 18-19
Online publication date: 1-Feb-2008.
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Albert J Eid, Raymund R Razonable. (2008) Cytomegalovirus disease in solid organ transplant recipients: advances lead to new challenges and opportunities. Current Opinion in Organ Transplantation 12:6, 610-617
Online publication date: 1-Jan-2008.
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Atul Humar. (2007) Cytomegalovirus Prevention: Prophylaxis and Preemptive Therapy. Transplantation 84:Supplement, S11-S14
Online publication date: 1-Oct-2007.
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R. K Avery. (2007) Valganciclovir Versus IV Ganciclovir for Therapy of Cytomegalovirus Viremia: Has Victory Been Achieved?. American Journal of Transplantation 7:9, 2062-2063
Online publication date: 1-Oct-2007.
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Federico Oppenheimer, Miguel Gonzalez-Molina, Marta Rubio. (2007) Cost of prophylaxis in the management of cytomegalovirus infection in solid organ transplant recipients. Clinical Transplantation 21:4, 441-448
Online publication date: 1-Aug-2007.
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A. Busca, P. de Fabritiis, V. Ghisetti, T. Allice, M. Mirabile, G. Gentile, F. Locatelli, M. Falda. (2007) Oral valganciclovir as preemptive therapy for cytomegalovirus infection post allogeneic stem cell transplantation. Transplant Infectious Disease 9:2, 102-107
Online publication date: 1-Jul-2007.
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John F. Spivey, Dana Singleton, Stuart Sweet, Gregory A. Storch, Robert J. Hayashi, Charles B. Huddleston, Lara A. Danziger-Isakov. (2007) Safety and efficacy of prolonged cytomegalovirus prophylaxis with intravenous ganciclovir in pediatric and young adult lung transplant recipients. Pediatric Transplantation 11:3, 312-318
Online publication date: 1-Jun-2007.
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J. A. Khoury, G. A. Storch, D. L. Bohl, R. M. Schuessler, S. M. Torrence, M. Lockwood, M. Gaudreault-Keener, M. J. Koch, B. W. Miller, K. L. Hardinger, M. A. Schnitzler, D. C. Brennan. (2006) Prophylactic Versus Preemptive Oral Valganciclovir for the Management of Cytomegalovirus Infection in Adult Renal Transplant Recipients. American Journal of Transplantation 6:9, 2134-2143
Online publication date: 1-Oct-2006.
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Yoshiyuki Yoda, Ryosuke Hanaoka, Hirotsugu Ide, Takeo Isozaki, Mizuho Matsunawa, Nobuyuki Yajima, Fumitaka Shiozawa, Yusuke Miwa, Masao Negishi, Tsuyoshi Kasama. (2006) Clinical evaluation of patients with inflammatory connective tissue diseases complicated by cytomegalovirus antigenemia. Modern Rheumatology 16:3, 137-142
Online publication date: 20-Jul-2006.
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Mark D Pescovitz. (2006) Valganciclovir: what is the status in solid organ transplantation?. Future Virology 1:2, 147-156
Online publication date: 1-Apr-2006.
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M.E. Levi, N. Mandava, L.K. Chan, A. Weinberg, J.L. Olson. (2006) Treatment of multidrug-resistant cytomegalovirus retinitis with systemically administered leflunomide. Transplant Infectious Disease 8:1, 38-43
Online publication date: 1-Apr-2006.
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  • Presented in part: American Transplant Congress meeting, Washington, DC, 22–25 May 2005 (abstract 902).

    Potential conflicts of interest: A.H. has received research support and honoraria from Roche Pharmaceuticals. No other author has a conflict of interest to declare.

    Financial support: Roche Pharmaceuticals.

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