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15 September 2005

Volume 41, Number 6
Clinical Infectious Diseases 2005;41:839–847
© 2005 by the Infectious Diseases Society of America. All rights reserved.
1058-4838/2005/4106-0014$15.00
DOI: 10.1086/432804
AGING AND INFECTIOUS DISEASES INVITED ARTICLE

Group B Streptococcal Infections in Elderly Adults

Morven S. Edwards1 and

Carol J. Baker1,2

Section of Infectious Disease, Departments of 1Pediatrics and 2Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas

Elderly adults account for >40% of persons with invasive group B streptococcal (GBS) disease and for >50% of GBS‐associated deaths in the United States. The prevalence of colonization among healthy elderly adults (25%) is similar to that among women of childbearing age. Delineating contributions of comorbid conditions, altered integrity of anatomical barriers, and abnormalities in immune responses caused by immune senescence to pathogenesis require further investigation. Delayed clinical recognition of illness may contribute to poor outcome. Skin and soft‐tissue infections and bacteremia with no identified focus are common manifestations of infection in elderly adults and younger nonpregnant adults. Urinary tract infection and pneumonia are presentations more often encountered in elderly persons than in younger adults. The safety and immunogenicity of GBS serotype V–tetanus toxoid conjugate vaccine in healthy elderly persons suggest the potential for vaccination as an approach to prevention of invasive GBS infections in elderly persons.

Received 4 May 2005; accepted 30 May 2005; electronically published 16 August 2005.

Reprints or correspondence: Dr. Morven S. Edwards, Dept. of Pediatrics, Section of Infectious Diseases, Rm. 302A, Baylor College of Medicine, Houston, TX 77030 ().

Kevin P. High, Section Editor

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