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15 September 2005

Volume 192, Number 6
The Journal of Infectious Diseases 2005;192:1108–1118
© 2005 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2005/19206-0024$15.00
DOI: 10.1086/432553
MAJOR ARTICLE

Praziquantel Treatment of Individuals Exposed to Schistosoma haematobium Enhances Serological Recognition of Defined Parasite Antigens

Francisca Mutapi,1

Richard Burchmore,2

Takafira Mduluza,3

Aude Foucher,2,a

Yvonne Harcus,1

Gavin Nicoll,1

Nicholas Midzi,4

C. Michael Turner,2 and

Rick M. Maizels1

1Institute for Immunology and Infection Research, Ashworth Laboratories, School of Biological Sciences, University of Edinburgh, Edinburgh, and 2Institute of Biomedical Life Sciences, Division of Infection and Immunity, University of Glasgow, Glasgow, United Kingdom; 3Department of Biochemistry, University of Zimbabwe, Mount Pleasant, and 4National Institute of Health Research, Causeway, Harare, Zimbabwe

Background.Schistosomiasis is a major parasitic disease affecting >200 million people in the developing world, and 400 million people are at risk for infection. This study aimed to identify and compare proteins recognized by serum samples from schistosome‐exposed individuals before and after curative praziquantel treatment.

Methods.Proteins recognized by pooled serum samples from Schistosoma haematobium–exposed Zimbabweans were determined by 2‐dimensional Western blotting and identified by mass spectrometry.

Results.Serum samples recognized 71 spots, which resolved to 26 different characterized proteins. Eleven of these proteins have not previously been shown to be immunogenic in natural human infection or in experimental models of schistosomiasis, making them novel antigens in the parasite. Pretreatment serum samples recognized 59 spots, which resolved to 21 different identified proteins. Posttreatment serum samples recognized an additional 12 spots, which resolved to 8 different identified proteins. Of these 8 proteins, 3 had putative isoforms recognized before treatment, and 5 (calreticulin, tropomyosin 1, tropomyosin 2, paramyosin, and triose phosphate isomerase) did not.

Conclusions.This study is the most comprehensive characterization of S. haematobium antigens to date and describes novel antigens in all schistosome species. Posttreatment results are consistent with praziquantel treatment inducing quantitative and qualitative changes in schistosome‐specific antibody responses.

Received 2 March 2005; accepted 11 April 2005; electronically published 5 August 2005.

Reprints or correspondence: Dr. Francisca Mutapi, Institute for Immunology and Infection Research, Ashworth Laboratories, School of Biological Sciences, University of Edinburgh, W. Mains Rd., Edinburgh EH9 3JT, United Kingdom ().

Cited by

Francisca Mutapi, Richard Burchmore, Takafira Mduluza, Nicholas Midzi, C. Michael R. Turner, and Rick M. Maizels. (2008) Age-Related and Infection Intensity–Related Shifts in Antibody Recognition of Defined Protein Antigens in a Schistosome-Exposed Population. The Journal of Infectious Diseases 198:2, 167-75
Online publication date: 15-Jul-2008.
Abstract-Full Text-PDF Version (478 kB)
Sandra Planchart, Renzo Nino Incani, Italo Mario Cesari. (2007) Preliminary characterization of an adult worm “vomit” preparation of Schistosoma mansoni and its potential use as antigen for diagnosis. Parasitology Research 101:2, 301-309
Online publication date: 22-Jun-2007.
CrossRef
Richard Burchmore. (2006) Identification of anti-infective targets through comparative proteomics. Expert Review of Anti-infective Therapy 4:2, 163-165
Online publication date: 1-May-2006.
CrossRef

  • Potential conflicts of interest: none reported.

    Financial support: Medical Research Council, United Kingdom (grant G81/538); Carnegie Trust for the Universities of Scotland; Wellcome Trust.

  • Present affiliation: Centre de Recherche en Infectiologie, Centre Hospitalier Universitaire de Quebec, Pavillion CHUL, Sainte Foy, Quebec, Canada.

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