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1 September 2005

Volume 192, Number 5
The Journal of Infectious Diseases 2005;192:801–810
© 2005 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2005/19205-0011$15.00
DOI: 10.1086/432515
MAJOR ARTICLE

The Predominant Variant of the Brazilian Epidemic Clonal Complex of Methicillin‐Resistant Staphylococcus aureus Has an Enhanced Ability to Produce Biofilm and to Adhere to and Invade Airway Epithelial Cells

Maribel M. Amaral,1,a

Leonardo R. Coelho,1,a

Rosania P. Flores,1

Raquel R. Souza,1

Maria C. Silva‐Carvalho,1

Lenise A. Teixeira,2

Bernadete T. Ferreira‐Carvalho,1 and

Agnes M. S. Figueiredo1

1Institute of Microbiology Professor Paulo de Góes, Federal University of Rio de Janeiro, and 2Faculty of Pharmacy, Fluminense Federal University, Rio de Janeiro, Brazil

Methicillin‐resistant Staphylococcus aureus (MRSA) has emerged as a therapeutic problem. In the present study, the molecular characterization by pulsed‐field gel electrophoresis of MRSA isolates collected from a university hospital revealed that the predominant variant of the Brazilian epidemic clonal complex (BECC) was responsible for the increase in the incidence of MRSA strains, which reached 28% in 1998. It was verified that this predominant variant of the BECC displayed an enhanced ability to produce biofilm on inert polystyrene surfaces and to adhere to and invade epithelial airway cells. These results indicate that MRSA strains belonging to the BECC have evolved advantageous properties that might play a role in their predominance as international nosocomial pathogens.

Received 30 November 2004; accepted 1 April 2005; electronically published 22 July 2005.

Reprints or correspondence: Dr. Agnes M. S. Figueiredo, Instituto de Microbiologia Prof. Paulo de Góes–UFRJ, Laboratório de Biologia Molecular de Bactérias, CCS, Bloco I, 2° andar, Cidade Universitária, Rio de Janeiro, RJ, 21941‐590, Brazil ().

Cited by

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Online publication date: 1-Mar-2009.
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Maria Cícera Silva-Carvalho, Lenise Arneiro Teixeira, Fabienne Antunes Ferreira, Apoena Ribeiro, Bernadete Teixeira Ferreira-Carvalho, Agnes Marie Sá Figueiredo. (2009) Comparison of different methods for detecting methicillin resistance in MRSA isolates belonging to international lineages commonly isolated in the American continent. Microbiology and Immunology 53:2, 117-122
Online publication date: 1-Mar-2009.
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L. R. Coelho, R. R. Souza, F. A. Ferreira, M. A. Guimaraes, B. T. Ferreira-Carvalho, A. M. S. Figueiredo. (2008) agr RNAIII divergently regulates glucose-induced biofilm formation in clinical isolates of Staphylococcus aureus. Microbiology 154:11, 3480-3490
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L. R. R. Perez, C. Dias, P. A. d'Azevedo. (2008) Agar dilution and agar screen with cefoxitin and oxacillin: what is known and what is unknown in detection of meticillin-resistant Staphylococcus aureus. Journal of Medical Microbiology 57:8, 954-956
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Rachel J. Gordon and Franklin D. Lowy. (2008) Pathogenesis of Methicillin‐Resistant Staphylococcus aureus Infection. Clinical Infectious Diseases 46:s5, S350-S359
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O. P. de Miranda, M. C. Silva-Carvalho, A. Ribeiro, F. Portela, R. P. Cordeiro, N. Caetano, C. F. L. Vidal, A. M. S. Figueiredo. (2008) Emergence in Brazil of methicillin-resistant Staphylococcus aureus isolates carrying SCCmecIV that are related genetically to the USA800 clone. Clinical Microbiology and Infection 13:12, 1165-1172
Online publication date: 1-Jan-2008.
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L. R. R. Perez, A. L. S. Antunes, A. L. Barth, P. A. d’Azevedo. (2007) Variations of agar screen tests for detection of methicillin resistance in staphylococci: focus on cefoxitin. European Journal of Clinical Microbiology & Infectious Diseases 26:4, 267-270
Online publication date: 4-May-2007.
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Ulrich Seybold and Henry M. Blumberg. (2007) Editorial Commentary: Reading the Tea Leaves or Deciphering DNA Microarrays: Are Certain Methicillin‐Resistant Staphylococcus aureus Clones Adapted to Cause Specific Infections?. Clinical Infectious Diseases 44:4, 502-505
Online publication date: 15-Feb-2007.
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Jonathan D. Edgeworth, Ghasem Yadegarfar, Smriti Pathak, Rahul Batra, Joshua D. Cockfield, Duncan Wyncoll, Richard Beale, and Jodi A. Lindsay. (2007) An Outbreak in an Intensive Care Unit of a Strain of Methicillin‐Resistant Staphylococcus aureus Sequence Type 239 Associated with an Increased Rate of Vascular Access Device–Related Bacteremia. Clinical Infectious Diseases 44:4, 493-501
Online publication date: 15-Feb-2007.
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  • Presented in part: 39th Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC), San Francisco, 26 September 1999 (abstract B1539); 44th ICAAC, Washington, DC, 30 October 2004 (abstract K1473).

    Potential conflicts of interest: none reported.

    Financial support: Conselho Nacional de Desenvolvimento Científico e Tecnológico (grants 473028/03 and 550652/2002‐70); Fundação de Apoio à Pesquisa do Estado do Rio de Janeiro (grant APQ1 to A.M.S.F.); Programa de Apoio a Núcleos de Excelência (grant to A.M.S.F.); Primeiros Projetos (grants to L.A.T. and B.T.F.‐C).

  • M.M.A. and L.R.C. contributed equally to this work.

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