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15 August 2005

Volume 192, Number 4
The Journal of Infectious Diseases 2005;192:681–684
© 2005 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2005/19204-0017$15.00
DOI: 10.1086/432073
BRIEF REPORT

Baseline Correlation and Comparative Kinetics of Cerebrospinal Fluid Colony‐Forming Unit Counts and Antigen Titers in Cryptococcal Meningitis

Annemarie E. Brouwer,1,3,6

Paprit Teparrukkul,2

Supraphada Pinpraphaporn,2

Robert A. Larsen,5

Wirongrong Chierakul,1

Sharon Peacock,1,4

Nicholas Day,1,4

Nicholas J. White,1,4 and

Thomas S. Harrison3

1Faculty of Tropical Medicine, Mahidol University, Bangkok, and 2Department of Medicine, Sappasitprasong Hospital, Ubon Ratchathani, Thailand; 3Department of Infectious Diseases, St. George’s Hospital Medical School, London, and 4Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom; 5Division of Infectious Diseases, Department of Medicine, University of Southern California, Los Angeles; 6Department of Internal Medicine and Infectious Diseases, University Medical Centre, Nijmegen, The Netherlands

Cerebrospinal fluid (CSF) cryptococcal colony‐forming unit counts and CSF cryptococcal antigen titers serve as alternative measures of organism load in cryptococcal meningitis. For these measures, we correlated baseline values and rates of decline during the first 2 weeks of therapy in 68 human immunodeficiency virus–seropositive patients with cryptococcal meningitis. At baseline, there was a strong correlation between CSF cryptococcal colony‐forming unit counts and CSF cryptococcal antigen titers. During the first 2 weeks of therapy, CSF cryptococcal colony‐forming unit counts decreased by >5 logs, and CSF cryptococcal antigen titers decreased by 1.5 dilutions. In individual patients, there was no correlation between the rate of decline in CSF cryptococcal colony‐forming unit counts and that in CSF cryptococcal antigen titers.

Received 26 January 2005; accepted 24 March 2005; electronically published 7 July 2005.

Reprints or correspondence: Dr. Thomas Harrison, Dept. of Infectious Diseases, St. George’s Hospital Medical School, London SW17 ORE, UK ().

Cited by

Joseph N. Jarvis, Stephen D. Lawn, Monica Vogt, Nonzwakazi Bangani, Robin Wood, and Thomas S. Harrison. (2009) Screening for Cryptococcal Antigenemia in Patients Accessing an Antiretroviral Treatment Program in South Africa. Clinical Infectious Diseases 48:7, 856-862
Online publication date: 1-Apr-2009.
Abstract-Full Text-PDF Version (319 kB)
Manjunath P Pai, Unal Sakoglu, Steven L Peterson, C Richard Lyons, Rohit Sood. (2009) Characterization of BBB permeability in a preclinical model of cryptococcal meningoencephalitis using magnetic resonance imaging. Journal of Cerebral Blood Flow & Metabolism 29:3, 545-553
Online publication date: 1-Apr-2009.
CrossRef
L. S. Chiapello, J. L. Baronetti, A. P. Garro, M. F. Spesso, D. T. Masih. (2008) Cryptococcus neoformans glucuronoxylomannan induces macrophage apoptosis mediated by nitric oxide in a caspase-independent pathway. International Immunology 20:12, 1527-1541
Online publication date: 1-Nov-2008.
CrossRef
W. G. Powderly. (2006) Antifungal treatment for cryptococcal meningitis. Internal Medicine Journal 36:7, 404-405
Online publication date: 1-Aug-2006.
CrossRef

  • Potential conflicts of interest: none reported.

    Financial support: Lancet International Fellowship (to A.E.B.); Wellcome Trust Training Fellowship (to A.E.B.); Netherlands Foundation for the Advancement of Tropical Research (WOTRO) (to A.E.B.); Wellcome Trust Advanced Training Fellowship (to T.S.H.); St. George’s Hospital Trustees; Wellcome Trust of Great Britain (support to Wellcome Trust–Mahidol University–Oxford Tropical Medicine Research Programme).

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