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1 September 2005 Supplement

Volume 192, Number S1
The Journal of Infectious Diseases 2005;192:S94–S99
© 2005 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2005/19205S1-0014$15.00
DOI: 10.1086/431505
SUPPLEMENT ARTICLE

Sentinel Hospital Surveillance for Rotavirus Diarrhea in the People’s Republic of China, August 2001–July 2003

Zhao‐Yin Fang,1

Bei Wang,3

Paul E. Kilgore,9

Joseph S. Bresee,10

Li‐Jie Zhang,1

Li‐Wei Sun,4

Zeng‐Qing Du,5

Jing‐Yu Tang,6

An‐Cun Hou,2

Hui Shen,7

Xiao‐Bo Song,8

Batmunkh Nyambat,9

Erik Hummelman,10

Zhi Y. Xu,9 and

Roger I. Glass10

1Viral Gastroenteritis Division, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, and 2Department of Pediatrics, Beijing Friendship Hospital, Beijing, 3Department of Epidemiology and Biostatistics, School of Public Health, Dongnan University, Nanjing, 4Department of Medical Research, Changchun Children’s Hospital, Changchun, Jilin Province, 5Department of Infectious Diseases, Kunming Children’s Hospital, Kunming, Yunnan Province, 6Lulong County Center for Disease Control and Prevention, Hebei Province, 7Suzhou Municipal Center for Disease Control and Prevention, Suzhou, Jiangsu Province, and 8Department of Pediatrics, MaAnShan Steel and Iron Trust Hospital, MaAnShan, Anhui Province, People's Republic of China; 9Division of Translational Research, International Vaccine Institute, Seoul, South Korea; 10Respiratory and Enteric Viruses Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia

China has the second largest birth cohort in the world and the second highest number of deaths due to rotavirus infection. It is also the only country with a licensed rotavirus vaccine. Chinese policy makers now need credible estimates of the burden of rotavirus disease, to decide about vaccine use. From August 2001 through July 2003, prospective hospital‐based surveillance for rotavirus diarrhea among children <5 years of age was conducted in 6 sentinel hospitals. Rotavirus isolates were characterized to determine the G and P genotypes circulating during the study. Of 3149 children who were admitted to the hospitals for diarrhea and for whom screening for rotavirus was performed, 1590 (50%) had positive results of an antigen detection assay. Of all episodes of rotavirus diarrhea, 95% occurred during the first 2 years of life. The most common rotavirus strain was P[8]G3 (49% of episodes), and all the common strains were detected, including G9 strains (4% of episodes). Ongoing efforts are under way to more precisely define the burden of rotavirus diarrhea in urban and rural populations, to assess the proportion of episodes that may be due to unusual or emerging strains, and to estimate the economic burden of rotavirus disease.

Reprints or correspondence: Dr. Zhao‐Yin Fang, Viral Gastroenteritis Division, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 100 Ying Xin St., Xuan Wu District, Beijing 100052, People’s Republic of China ().

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  • Presented in part: 3rd Asian Rotavirus Surveillance Network Investigators’ Meeting, Manila, The Philippines, 21–22 October 2003.

    Financial support: Children’s Vaccine Program at the Program for Appropriate Technology in Health; Department of Vaccines and Biologicals, World Health Organization (grant V27/181/123).

    Potential conflicts of interest: none reported.

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