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1 September 2005 Supplement

Volume 192, Number S1
The Journal of Infectious Diseases 2005;192:S30–S35
© 2005 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2005/19205S1-0005$15.00
DOI: 10.1086/431498
SUPPLEMENT ARTICLE

Development of Candidate Rotavirus Vaccines Derived from Neonatal Strains in India

Roger I. Glass,1

Maharaj K. Bhan,4

Pratima Ray,4

Rajiv Bahl,4

Umesh D. Parashar,1

Harry Greenberg,2

C. Durga Rao,5

Nita Bhandari,4

Yvonne Maldonado,2

Richard L. Ward,3

David I. Bernstein,3 and

Jon R. Gentsch1

1Respiratory and Enteric Viruses Branch, Centers for Disease Control and Prevention, Atlanta, Georgia; 2Stanford University Medical School, Palo Alto, California; 3Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; 4Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, and 5India Institute of Science, Bangalore, India

The need for a rotavirus vaccine in India is based on the enormous burden associated with the >100,000 deaths due to rotavirus diarrhea that occur annually among Indian children. Two rotavirus strains identified during nosocomial outbreaks of rotavirus infection in New Delhi and Bangalore, India, more than a decade ago are being developed as live oral vaccines. Infected newborns had no symptoms, shed virus for up to 2 weeks after infection, mounted a robust immune response, and demonstrated protection against severe rotavirus diarrhea after reinfection. The 2 strains are naturally occurring bovine‐human reassortants. The New Delhi strain, 116E, is characterized as having a P[11],G9 genotype, and the Bangalore strain, I321, is characterized as having a P[11],G10 genotype. The strains have been prepared as pilot lots for clinical trials to be conducted in New Delhi. This unique project, which is developing a new rotavirus vaccine in India with the use of Indian strains, an Indian manufacturer, and an Indian clinical development program, aims to expedite introduction of rotavirus vaccines in India.

Reprints or correspondence: Dr. Roger I. Glass, Mailstop G04, CDC, 1600 Clifton Rd., Atlanta, GA 30333 ().

Cited by

Nita Bhandari, Pooja Sharma, Sunita Taneja, Tivendra Kumar, Temsunaro Rongsen‐Chandola, Mohan Babu Appaiahgari, Arpita Mishra, Shakti Singh, Sudhanshu Vrati, and the Rotavirus Vaccine Development Group. (2009) A Dose‐Escalation Safety and Immunogenicity Study of Live Attenuated Oral Rotavirus Vaccine 116E in Infants: A Randomized, Double‐Blind, Placebo‐Controlled Trial. The Journal of Infectious Diseases 200:3, 421-429
Online publication date: 1-Aug-2009.
Abstract-Full Text-PDF Version (363 kB)
Sasirekha Ramani, Thuppal V. Sowmyanarayanan, Beryl Primrose Gladstone, Kaushik Bhowmick, Jaya Ruth Asirvatham, Atanu Kumar Jana, Kurien Anil Kuruvilla, Manish Kumar, Sridhar Gibikote, Gagandeep Kang. (2008) Rotavirus Infection in the Neonatal Nurseries of a Tertiary Care Hospital in India. The Pediatric Infectious Disease Journal 27:8, 719-723
Online publication date: 1-Sep-2008.
CrossRef
Philippe Lepage, Anne Vergison. (2008) Prevention of childhood rotavirus disease through the use of Rotarix™ and RotaTeq™ vaccines. Expert Opinion on Biological Therapy 7:12, 1881-1892
Online publication date: 1-Jan-2008.
CrossRef
Albert Z. Kapikian and Yasutaka Hoshino. (2007) To Serotype or Not To Serotype: That Is Still the Question. The Journal of Infectious Diseases 195:5, 611-614
Online publication date: 1-Mar-2007.
Citation-Full Text-PDF Version (172 kB)
Indrani Banerjee, Beryl Primrose Gladstone, Andrea M. Le Fevre, Sasirekha Ramani, Miren Iturriza‐Gomara, James J. Gray, David W. Brown, Mary K. Estes, Jaya Prakash Muliyil, Shabbar Jaffar, and Gagandeep Kang. (2007) Neonatal Infection with G10P[11] Rotavirus Did Not Confer Protection against Subsequent Rotavirus Infection in a Community Cohort in Vellore, South India. The Journal of Infectious Diseases 195:5, 625-632
Online publication date: 1-Mar-2007.
Abstract-Full Text-PDF Version (273 kB)
Joseph S. Bresee, Erik Hummelman, E. A. S. Nelson, and Roger I. Glass. (2005) Rotavirus in Asia: The Value of Surveillance for Informing Decisions about the Introduction of New Vaccines. The Journal of Infectious Diseases 192:s1, S1-S5
Online publication date: 1-Sep-2005.
Citation-Full Text-PDF Version (790 kB)
Roger I. Glass, Joseph S. Bresee, Reina Turcios, Thea K. Fischer, Umesh D. Parashar, and A. Duncan Steele. (2005) Rotavirus Vaccines: Targeting the Developing World. The Journal of Infectious Diseases 192:s1, S160-S166
Online publication date: 1-Sep-2005.
Abstract-Full Text-PDF Version (96 kB)

  • Financial support: Bill and Melinda Gates Foundation (to the Program for Appropriate Technology in Health, through the Andra Pradesh Initiative); National Institutes of Health (grants AI‐21362 and AI‐53719); Department of Biotechnology of the Government of India; Indo‐US Vaccine Action Program.

    Potential conflicts of interest: none reported.

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