All Journals > The Journal of Infectious Diseases > 1 September 2005 > Incidence of Severe Rotavirus Diarrhea

Article Tools

Search for Related Articles

  • By Author
  • Search In

Announcements

Science Watch logo

JID Article Named "New Hot Paper" by ScienceWatch.com

Dr. Lauri Hicks' 2007 article on pneumococcal disease has been named a "hot new paper" by Thompson Reuters' ScienceWatch.com. Read a Q&A about the article with Dr. Hicks here. 

Press Release

Unique Collaboration Charts the Migrations of a Parasite that Affected History
Researchers Sequence Louse DNA from Mummies and Propose New Model for its Development


In the News

Featured in Grist
"Another symptom of swine flu: instant amnesia" May 11, 2009
Swine Influenza Virus: Zoonotic Potential and Vaccination Strategies for the Control of Avian and Swine Influenzas
Eileen Thacker and Bruce Janke
Read the veterinary literature on swine flu and you get a strong sense of what might be called vaccination treadmill: the hog industry is literally scrambling to generate new vaccines for the rapidly evolving flu strains that sweep through CAFOs. Writing in the Journal of Infectious Diseases [PDF] in 2008, Eileen Thacker and Bruce Janke of Iowa State University paint a stark picture: “A number of genetically diverse viruses are circulating in swine herds throughout the world and are a major cause of concern to the swine industry,” they write. “Influenza virus infections in swine and poultry are potential sources of viruses for the next pandemic among humans.”

Featured in New York Times
"Fear of a Swine Flu Epidemic in 1976 Offers Some Lessons, and Concerns, Today" May 8, 2009
Anti‐Ganglioside Antibody Induction by Swine (A/NJ/1976/H1N1) and Other Influenza Vaccines: Insights into Vaccine‐Associated Guillain‐Barré Syndrome
Irving Nachamkin, Sean V. Shadomy, Anthony P. Moran, Nancy Cox, Collette Fitzgerald, Huong Ung, Adrian T. Corcoran, John K. Iskander, Lawrence B. Schonberger, and Robert T. Chen
Irving Nachamkin, a professor of pathology and laboratory medicine at the University of Pennsylvania, examined some 1976 vaccine that had been saved by a scientist in Texas. In a paper published last year in The Journal of Infectious Diseases, he and colleagues reported that mice given the vaccine made antibodies that reacted with gangliosides, which are components of nerve cells. An antibody attack on gangliosides is part of the disease mechanism of Guillain-Barré.

Featured in AFP
"Swine flu vaccine 'could be ready soon'" May 7, 2009
A Broadly Protective Vaccine against Globally Dispersed Clade 1 and Clade 2 H5N1 Influenza Viruses
Mary A. Hoelscher, Neetu Singh, Sanjay Garg, Lakshmi Jayashankar, Vic Veguilla, Aseem Pandey, Yumi Matsuoka, Jacqueline M. Katz, Ruben Donis, Suresh K. Mittal, and Suryaprakash Sambhara
The vaccine Mittal created for the bird flu worked on three different strains isolated over a seven-year period and was described in papers for the Journal of Infectious Diseases and the journal Clinical Pharmacology and Therapeutics.

Featured in Newsweek
"The Path of a Pandemic" http://www.newsweek.com/id/195692
Swine Influenza Virus: Zoonotic Potential and Vaccination Strategies for the Control of Avian and Swine Influenzas
Eileen Thacker and Bruce Janke
Last year researchers from Iowa State University in Ames warned that pigs located in industrial-scale farms were being subjected to influenza infections from farm poultry, wild birds and their human handlers. Writing in The Journal of Infectious Diseases, Eileen Thacker and Bruce Janke said, "As a result of the constantly changing genetic makeup of individual influenza viruses in pigs, the U.S. swine industry is continually scrambling to respond to the influenza viruses circulating within individual production systems."

1 September 2005 Supplement

Volume 192, Number S1
The Journal of Infectious Diseases 2005;192:S114–S119
© 2005 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2005/19205S1-0018$15.00
DOI: 10.1086/431497
SUPPLEMENT ARTICLE

Incidence of Severe Rotavirus Diarrhea in New Delhi, India, and G and P Types of the Infecting Rotavirus Strains

Rajiv Bahl,1

Pratima Ray,1

Swati Subodh,1

Prashant Shambharkar,1

Manju Saxena,1

Umesh Parashar,2

Jon Gentsch,2

Roger Glass,2 and

M. K. Bhan,1 for the

Delhi Rotavirus Study Groupa

1Center for Diarrheal Disease and Nutrition Research, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India; 2Viral Gastroenteritis Division, Centers for Disease Control and Prevention, Atlanta, Georgia

A total of 62,475 children <5 years old from a defined population of 500,000 children and adults from slums in New Delhi, India, were assessed for 1 year by means of passive surveillance, to identify children who were hospitalized for diarrhea. The incidence of severe rotavirus diarrhea was estimated, and the G and P types of the infecting rotavirus strains were determined and were correlated with the clinical severity of diarrhea. Of 584 children who were hospitalized with diarrhea, 137 (23.5%) had rotavirus detected in stool specimens (incidence of rotavirus diarrhea–associated hospitalizations, 337 hospitalizations/100,000 children <5 years of age). Most cases of diarrhea (98%) occurred during the first 2 years of life, peaking at 9–11 months of age. Rotavirus‐associated diarrhea occurred year‐round but was predominant in winter. Among the strains that could be G‐typed, G1 was the most common serotype, followed by G9 and G2; 10% of cases of diarrhea were due to mixed G‐type infections. Common strains identified in the present surveillance study were P[8]G1, P[4]G2, P[8]G9, P[6]G1, P[6]G9, and P[6]G3. Children infected with G1 strains had a greater risk of developing more‐severe cases of diarrhea than did children infected with other rotavirus strains (odds ratio, 2.95; 95% confidence interval, 1.3–6.67).

Reprints or correspondence: Prof. M. K. Bhan, Dept. of Pediatrics, All India Institute of Medical Sciences, New Delhi 110029, India ().

Cited by

Preeti Chhabra, Ramchandra K. Dhongade, Vijay R. Kalrao, Ashish R. Bavdekar, Shobha D. Chitambar. (2009) Epidemiological, clinical, and molecular features of norovirus infections in western India. Journal of Medical Virology 81:5, 922-932
Online publication date: 1-Jun-2009.
CrossRef
Shally Awasthi, Girdhar G Agarwal, Vikas Mishra, Vijay Laxmi Nag, Hesham Fathey El Sayed, Antonio Jose Ledo da Cunha, Alvaro Madeiro, Dipty Jain, William M Macharia, James Ndung'u, Saumya Awasthi, Ashish Wakhlu. (2009) Four-country surveillance of intestinal intussusception and diarrhoea in children. Journal of Paediatrics and Child Health 45:3, 82-86
Online publication date: 1-Apr-2009.
CrossRef
Yu Jin, Xin-Hua Ye, Zhao-Yin Fang, Yu-Ning Li, Xue-Mei Yang, Qiao-Li Dong, Xiang Huang. (2008) Molecular epidemic features and variation of rotavirus among children with diarrhea in Lanzhou, China, 2001–2006. World Journal of Pediatrics 4:3, 197-201
Online publication date: 1-Sep-2008.
CrossRef
Gulendam Bozdayi, Bora Dogan, Buket Dalgic, Ilknur Bostanci, Sinan Sari, Nergis Oner Battaloglu, Seyyal Rota, Yildiz Dallar, Akira Nishizono, Osamu Nakagomi, Kamruddin Ahmed. (2008) Diversity of human rotavirus G9 among children in Turkey. Journal of Medical Virology 80:4, 733-740
Online publication date: 1-May-2008.
CrossRef
Evan J. Anderson. (2007) Rotavirus G9 Severity Data Revisited. Clinical Infectious Diseases 44:1, 154-155
Online publication date: 1-Jan-2007.
Citation-Full Text-PDF Version (338 kB)
Pratima Ray, Martijn Fenaux, Sumit Sharma, Jyoti Malik, Swati Subodh, Shinjini Bhatnagar, Harry Greenberg, Roger I. Glass, Jon Gentsch, and M. K. Bhan. (2006) Quantitative Evaluation of Rotaviral Antigenemia in Children with Acute Rotaviral Diarrhea. The Journal of Infectious Diseases 194:5, 588-593
Online publication date: 1-Sep-2006.
Abstract-Full Text-PDF Version (112 kB)
Gagandeep Kang. (2006) Editorial Commentary: Rotavirus Genotypes and Severity of Diarrheal Disease. Clinical Infectious Diseases 43:3, 315-316
Online publication date: 1-Aug-2006.
Citation-Full Text-PDF Version (53 kB)
Laura Jean Podewils, Lynn Antil, Erik Hummelman, Joseph Bresee, Umesh D. Parashar, and Richard Rheingans. (2005) Projected Cost‐Effectiveness of Rotavirus Vaccination for Children in Asia. The Journal of Infectious Diseases 192:s1, S133-S145
Online publication date: 1-Sep-2005.
Abstract-Full Text-PDF Version (133 kB)

  • Financial support: Department of Vaccines and Biologicals, World Health Organization; Children’s Vaccine Program at the Program for Appropriate Technology in Health.

    Potential conflicts of interest: none reported.

  • Members of the study group are listed at the end of the text.

Back to Top
Close Popup