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1 July 2005

Volume 192, Number 1
The Journal of Infectious Diseases 2005;192:71–78
© 2005 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2005/19201-0012$15.00
DOI: 10.1086/430743
MAJOR ARTICLE

Inhibition of HIV‐1 Replication in Human Lymphoid Tissues Ex Vivo by Measles Virus

Jean‐Charles Grivel,1

Mayra García,2,3

William J. Moss,2,4 and

Leonid B. Margolis1

1Laboratory of Molecular and Cellular Biophysics, National Institute of Child Health and Human Development, Bethesda, 2W. Harry Feinstone Department of Molecular Microbiology and Immunology and 3Cellular Molecular Medicine, School of Medicine, Johns Hopkins University, and 4Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland

Human immunodeficiency virus (HIV) type 1 replication and disease progression are enhanced by various pathogens in coinfected individuals. However, acute infection with measles virus (MV) has been found to suppress HIV‐1 replication in coinfected children. We investigated the mechanisms of this phenomenon using human lymphoid tissues coinfected ex vivo with HIV‐1 and MV. MV inhibited both CXCR4‐tropic (X4) and CCR5‐tropic (R5) HIV‐1, but the inhibitory effect was particularly profound for R5 virus, which transmits infection and dominates the early stages of HIV‐1 disease. MV inhibits the replication of R5 HIV‐1 in coinfected tissues by up‐regulation of the CC chemokine RANTES, a well‐known inhibitor of R5 HIV‐1 infection, and this up‐regulation is augmented in tissues coinfected with R5 HIV‐1. Deciphering the molecular mechanisms by which MV and other pathogens alter local cytokine/chemokine networks and cause tissue microenvironments to become detrimental to HIV‐1 may significantly contribute to the development of effective anti‐HIV therapies.

Received 18 December 2004; accepted 9 February 2005; electronically published 31 May 2005.

Reprints or correspondence: Dr. Leonid B. Margolis, NIH, Bldg. 10, Rm. 9D58, 10 Center Dr., Bethesda, MD 20892 (); Dr. William J. Moss, Bloomberg School of Public Health, JHU, 615 N. Wolfe St., Rm. E6545, Baltimore, MD 21205 ().

Cited by

Jean-Charles Grivel, Leonid Margolis. (2009) Use of human tissue explants to study human infectious agents. Nature Protocols 4:2, 256-269
Online publication date: 1-Mar-2009.
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William J. Moss, Susana Scott, Zaza Ndhlovu, Mwaka Monze, Felicity T. Cutts, Thomas C. Quinn, Diane E. Griffin. (2009) SUPPRESSION OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 VIRAL LOAD DURING ACUTE MEASLES. The Pediatric Infectious Disease Journal 28:1, 63-65
Online publication date: 1-Feb-2009.
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Theodore D Ruel, Jane Achan, Anne F Gasasira, Edwin D Charlebois, Tsedal Mehbratu, Philip J Rosenthal, Grant Dorsey, Moses R Kamya, Adeodata Kekitiinwa, Joseph Wong, Diane V Havlir. (2008) HIV RNA Suppression Among HIV-Infected Ugandan Children With Measles. JAIDS Journal of Acquired Immune Deficiency Syndromes 48:2, 225-227
Online publication date: 1-Jul-2008.
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M. Garcia, X.-F. Yu, D. E. Griffin, W. J. Moss. (2008) Measles virus inhibits human immunodeficiency virus type 1 reverse transcription and replication by blocking cell-cycle progression of CD4+ T lymphocytes. Journal of General Virology 89:4, 984-993
Online publication date: 1-May-2008.
CrossRef
Angélique Biancotto, Sarah J. Iglehart, Andrea Lisco, Christophe Vanpouille, Jean-Charles Grivel, Nell S. Lurain, Patricia S. Reichelderfer, Leonid B. Margolis. (2008) Upregulation of Human Cytomegalovirus by HIV Type 1 in Human Lymphoid Tissue ex Vivo. AIDS Research and Human Retroviruses 24:3, 453-462
Online publication date: 1-Apr-2008.
CrossRef
Cristian Condack, Jean‐Charles Grivel, Patricia Devaux, Leonid Margolis, and Roberto Cattaneo. (2007) Measles Virus Vaccine Attenuation: Suboptimal Infection of Lymphatic Tissue and Tropism Alteration. The Journal of Infectious Diseases 196:4, 541-549
Online publication date: 15-Aug-2007.
Abstract-Full Text-PDF Version (778 kB)

  • Financial support: National Institute of Child Health and Human Development Intramural Program (to J.‐C.G. and L.B.M.); Elizabeth Glaser Pediatric AIDS Foundation (grant PG‐51331 to M.G. and W.J.M.).

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