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1 June 2005

Volume 191, Number 11
The Journal of Infectious Diseases 2005;191:1988–1991
© 2005 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2005/19111-0027$15.00
DOI: 10.1086/429964
BRIEF REPORT

Influence of Interleukin‐10 on Aspergillus fumigatus Infection in Patients with Cystic Fibrosis

Jacques Brouard,1,5

Nicola Knauer,1,9

Pierre‐Yves Boelle,4

Harriet Corvol,1,2

Alexandra Henrion‐Caude,1

Cyril Flamant,1

François Bremont,6

Bertrand Delaisi,3

Jean‐Francois Duhamel,5

Christophe Marguet,7

Michel Roussey,8

Marie‐Claude Miesch,1

Katarina Chadelat,1,2

Michele Boule,1,2

Brigitte Fauroux,1,2

Felix Ratjen,9

Hartmut Grasemann,9 and

Annick Clement1,2

1Inserm E213 and 2Department of Pediatric Pneumology, Armand Trousseau Hospital, 3Department of Pediatrics, Robert Debré Children’s Hospital, and 4Department of Biostatistics, Inserm U444, St‐Antoine Hospital, Paris, and 5Department of Pediatrics, Georges Clémenceau Hospital, Caen, and 6Department of Pneumology and Gastroenterology, Purpan Children’s Hospital, Toulouse, and 7Department of Pediatrics, Charles Nicolle Hospital, Rouen, and 8Department of Pediatrics, South Hospital, Rennes, France; 9Children’s Hospital, University of Essen, Essen, Germany

Recent evidence suggests that genetic polymorphisms that affect the production of interleukin (IL)–10 may play a role in the response to pathogens in cystic fibrosis (CF). The present study was designed to investigate a possible association between alleles carried at position −1082 in the promoter region of the IL‐10 gene and clinical data on 378 patients with CF. After adjustment for potential confounding variables, a significant relationship was found between the −1082GG genotype and both colonization with Aspergillus fumigatus and allergic bronchopulmonary aspergillosis. In addition, higher serum levels of IL‐10 were observed in patients colonized with A. fumigatus. These results suggest that polymorphisms in the promoter region of the IL‐10 gene may influence the host response to A. fumigatus in the context of CF.

Received 9 November 2004; accepted 8 January 2005; electronically published 25 April 2005.

Reprints or correspondence: Dr. Jacques Brouard, Dept. of Pediatrics, Georges Clémenceau Hospital, Ave. Georges Clémenceau, 14033 Caen Cedex, France ().

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Nichole T. Tanner, Marc A. Judson. (2009) Diagnosis and treatment of allergic bronchopulmonary aspergillosis. Current Fungal Infection Reports 2:4, 199-205
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Joseph M Collaco, Garry R Cutting. (2008) Update on gene modifiers in cystic fibrosis. Current Opinion in Pulmonary Medicine 14:6, 559-566
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J. Sainz, E. Pérez, S. Gómez-Lopera, M. Jurado. (2008) IL1 Gene Cluster Polymorphisms and Its Haplotypes may Predict the Risk to Develop Invasive Pulmonary Aspergillosis and Modulate C-reactive Protein Level. Journal of Clinical Immunology 28:5, 473-485
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Christine Virnig, Robert K Bush. (2007) Allergic bronchopulmonary aspergillosis: a US perspective. Current Opinion in Pulmonary Medicine 13:1, 67???71
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Rainer Büscher, Hartmut Grasemann. (2006) Disease modifying genes in cystic fibrosis: therapeutic option or one-way road?. Naunyn-Schmiedeberg's Archives of Pharmacology 374:2, 65-77
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H. Sambatakou, V. Pravica, I. V. Hutchinson, D. W. Denning. (2006) Cytokine profiling of pulmonary aspergillosis. International Journal of Immunogenetics 33:4, 297-302
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  • Presented in part: 18th North American Cystic Fibrosis Conference, St. Louis, Missouri, 14–17 October 2004 (abstract 103).

    Financial support: Institut National de la Santé et de la Recherche Médicale; Assistance Publique‐Hôpitaux de Paris; Université Pierre et Marie Curie Paris; Association Vaincre La Mucoviscidose; Chancellerie des Universités (Legs Poix); Association Agir Informer Contre la Mucoviscidose; European Respiratory Society (fellowship to N.K.).

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