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15 May 2005

Volume 40, Number 10
Clinical Infectious Diseases 2005;40:1429–1434
1058-4838/2005/4010-0008$15.00
DOI: 10.1086/429628
MAJOR ARTICLE

Use of Long‐Acting Tetracyclines for Methicillin‐Resistant Staphylococcus aureus Infections: Case Series and Review of the Literature

Jörg J. Ruhe,

Thomas Monson,

Robert W. Bradsher, and

Anupama Menon

Division of Infectious Diseases, Department of Medicine, University of Arkansas for Medical Sciences and the Central Arkansas Veterans Healthcare System, Little Rock, Arkansas

Background.Few data exist on the efficacy of the long‐acting tetracyclines doxycycline and minocycline against methicillin‐resistant Staphylococcus aureus (MRSA) infection.

Methods.The medical records of 24 patients with serious tetracycline‐susceptible MRSA infections who were treated with doxycycline or minocycline were reviewed. A review of the literature on the use of these antibiotics for treatment of both methicillin‐susceptible and methicillin‐resistant S. aureus infection was also performed.

Results.Complicated skin and skin‐structure infections were most common (67%). Clinical cure was achieved in 20 (83%) of 24 patients in our case series. Both drugs were well‐tolerated. The review of the literature on a total of 85 patients with S. aureus infection revealed similar results.

Conclusions.Long‐acting tetracyclines may be a reasonable treatment alternative for patients with certain types of MRSA infection.

Received 8 November 2004; accepted 11 January 2005; electronically published 6 April 2005.

Reprints or correspondence: Dr. Jörg J Ruhe, Div. of Infectious Diseases, University of Arkansas for Medical Sciences, 4301 W. Markham St., Slot #639, Little Rock, AR 72205 ().

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