Division of Infectious Diseases, Department of Medicine, University of Arkansas for Medical Sciences and the Central Arkansas Veterans Healthcare System, Little Rock, Arkansas
Background.
Few data exist on the efficacy of the long‐acting tetracyclines doxycycline and minocycline against methicillin‐resistant Staphylococcus aureus (MRSA) infection.
Methods.
The medical records of 24 patients with serious tetracycline‐susceptible MRSA infections who were treated with doxycycline or minocycline were reviewed. A review of the literature on the use of these antibiotics for treatment of both methicillin‐susceptible and methicillin‐resistant S. aureus infection was also performed.
Results.
Complicated skin and skin‐structure infections were most common (67%). Clinical cure was achieved in 20 (83%) of 24 patients in our case series. Both drugs were well‐tolerated. The review of the literature on a total of 85 patients with S. aureus infection revealed similar results.
Conclusions.
Long‐acting tetracyclines may be a reasonable treatment alternative for patients with certain types of MRSA infection.
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