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1 May 2005

Volume 191, Number 9
The Journal of Infectious Diseases 2005;191:1468–1471
© 2005 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2005/19109-0013$15.00
DOI: 10.1086/429412
BRIEF REPORT

Infection with HIV‐1 Induces a Decrease in mtDNA

Miriam Casula,1

Irene Bosboom‐Dobbelaer,2

Karlijn Smolders,2

Sigrid Otto,3

Margreet Bakker,4

Michel P. de Baar,2

Peter Reiss,5 and

Anthony de Ronde4

1International Antiviral Therapy Evaluation Center, 2Primagen, 3Department of Clinical Viro‐Immunology, Sanquin Research at Central Laboratory Blood Transfusion Service, and Departments of 4Human Retrovirology and 5Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Cross‐sectional studies have suggested that infection with human immunodeficiency virus (HIV) type 1 could reduce the mitochondrial DNA (mtDNA) content of blood cells. We investigated mtDNA content in peripheral blood mononuclear cells (PBMCs) obtained from 36 antiretroviral therapy–naive documented HIV‐1 seroconverters, before and after seroconversion. mtDNA content statistically significantly decreased 1 year after seroconversion and showed a nonsignificant decrease during the subsequent 4 years. These findings confirm that infection with HIV‐1 may, itself, reduce mtDNA content, at least within PBMCs. This could have implications for the subsequent development of mitochondrial toxicities associated with the use of nucleoside analogue reverse‐transcriptase inhibitors.

Received 11 October 2004; accepted 10 December 2004; electronically published 25 March 2005.

Reprints or correspondence: Miriam Casula, Meibergdreef 9, PO Box 22700, 1100 DE Amsterdam, The Netherlands (, ).

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