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15 April 2005

Volume 40, Number 8
Clinical Infectious Diseases 2005;40:1123–1130
© 2005 by the Infectious Diseases Society of America. All rights reserved.
1058-4838/2005/4008-0008$15.00
DOI: 10.1086/428730
MAJOR ARTICLE

Association between Chlamydia pneumoniae and Acute Myocardial Infarction in Young Men in the United States Military: The Importance of Timing of Exposure Measurement

Christine M. Arcari,1

Charlotte A. Gaydos,2

F. Javier Nieto,1

Margot Krauss,4 and

Kenrad E. Nelson3

1University of Wisconsin Medical School, Madison; 2Johns Hopkins University School of Medicine and 3Johns Hopkins University Bloomberg School of Public Health, Baltimore, and 4Walter Reed Army Institute of Research, Silver Spring, Maryland

Background.Several investigators have found that Chlamydia pneumoniae and cytomegalovirus infections may be risk factors for coronary heart disease. However, the data remain controversial. To address this hypothesis, data and specimens were collected from a well‐established prospective cohort of active‐duty personnel from the US military.

Methods.A nested case‐control study was conducted with 300 case patients and 300 matched control subjects. Case patients were men (age, 30–50 years) with a medically documented, first‐time hospitalization for acute myocardial infarction (MI) and from whom a serum specimen had been drawn 1 year before the time of the acute MI. Population‐based control subjects were chosen from the same cohort and were individually matched by age, race, and time of specimen collection. Evidence of past infections with C. pneumoniae and cytomegalovirus were measured by microimmunofluorescence assay and enzyme‐linked immunosorbent assay, respectively.

Results.Significant risk was associated with high titer (1:64) to C. pneumoniae immunoglobulin A (IgA) (adjusted relative risk [RRadj], 1.67; 95% confidence interval [CI], 1.04–2.70). This increased risk was greatest when specimens were collected 1–5 years before the event (RRadj, 2.11; 95% CI, 1.06–4.21). High titer (1:256) to C. pneumoniae immunoglobulin G (IgG) was also associated with an elevated risk (RRadj, 1.74; 95% CI, 0.90–3.34) after full adjustment for cardiovascular risk factors, whereas no independent risk for acute MI was associated with cytomegalovirus IgG seropositivity.

Conclusions.This study demonstrates a significant association between high titers to C. pneumoniae IgG and IgA and acute MI in a cohort of young men and suggests that recent or chronic active infections could be associated with an increased risk for MI.

Received 9 June 2004; accepted 3 December 2004; electronically published 14 March 2005.

  • (See the editorial commentary by Grayston on pages 1131–2)

Reprints or correspondence: Dr. Christine M. Arcari, Population Health Sciences, 605 WARF, 610 Walnut St., Madison, WI 53726 ().

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Christine M. Arcari, Kenrad E. Nelson, Dale M. Netski, F. Javier Nieto, and Charlotte A. Gaydos. (2006) No Association between Hepatitis C Virus Seropositivity and Acute Myocardial Infarction. Clinical Infectious Diseases 43:6, e53-e56
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J. Thomas Grayston. (2005) Editorial Commentary: Chlamydia pneumoniae and Atherosclerosis. Clinical Infectious Diseases 40:8, 1131-1132
Online publication date: 15-Apr-2005.
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