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15 March 2005

Volume 191, Number 6
The Journal of Infectious Diseases 2005;191:907–916
© 2005 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2005/19106-0012$15.00
DOI: 10.1086/428287
MAJOR ARTICLE

The Natural Course of Chlamydia trachomatis Infection in Asymptomatic Colombian Women: A 5‐Year Follow‐Up Study

Mónica Molano,1,4

Chris J. L. M. Meijer,1

Elisabete Weiderpass,3

Annie Arslan,3

Hector Posso,4

Silvia Franceschi,3

Margarita Ronderos,4

Nubia Muñoz,3 and

Adriaan J. C. van den Brule1,2

1Department of Pathology, Vrije Universiteit Medical Center, Amsterdam, and 2Laboratory for Pathology and Medical Microbiology, PAMM Institute, Eindhoven, The Netherlands; 3Unit of Field and Intervention Studies, International Agency for Research on Cancer, Lyon, France; 4División de Investigación, Instituto Nacional de Cancerología, Bogota, Colombia

The natural course of Chlamydia trachomatis infection and its risk factors were studied in Colombian women with normal cytological results, during a 5‐year period. Eighty‐two women who were found to be positive for C. trachomatis at the start of the study were studied at 6‐month intervals. At each visit, a cervical scrape sample was obtained for detection of C. trachomatis by use of C. trachomatis endogenous‐plasmid polymerase chain reaction (PCR)–enzyme immunoassay and VD2‐PCR–reverse line blot assay. Of the women studied, 67% had a single‐serovar infection, 10% had a mixed‐serovar infection, and 23% had an infection with an unidentified type. An inversed rate of clearance of C. trachomatis infection was observed with oral contraceptive use (hazard ratio [HR], 1.7 [95% confidence interval {CI}, 1.1–2.7]) and first sexual intercourse at 20 years of age (HR, 4.3 [95% CI, 2.3–8.0]). Serovars of group B (B, D, and E) and C (H, I, J, and K) had a decreased rate of clearance (rate ratio, 0.4 [95% CI, 0.1–0.9]), compared with that for serovars of the intermediate group (F and G). At 4 years of follow‐up, 94% of the women had cleared their infections.

Received 7 June 2004; accepted 14 October 2004; electronically published 9 February 2005.

Reprints or correspondence: Dr. A. J. C. van den Brule, Laboratory for Pathology and Medical Microbiology, PAMM Institute, Michelangelolaan 2, 5623 EJ Eindhoven, The Netherlands ().

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  • Financial support: Colciencias of the Colombian Government (fellowship to M.M.); Vrije Universiteit Medical Center, Department of Pathology; Instituto Nacional de Cancerologìa, Department of Epidemiology; World Health Organization; International Agency for Research on Cancer.

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