Cross‐Serotype Neutralization of Dengue Virus in Aotus nancymae Monkeys
1US Naval Medical Research Center Detachment, Lima, Peru; 2Uniformed Services University of Health Sciences, Bethesda, and 3US Naval Medical Research Center, Silver Spring, Maryland
Previously, we observed that serum from humans immune to dengue serotype 1 (dengue‐1) neutralized the American genotype of dengue serotype 2 (American‐2) to a greater extent than it neutralized the Asian genotype of dengue serotype 2 (Asian‐2). To determine if this activity is protective, Aotus nancymae monkeys were infected with dengue‐1 followed by either American‐2 or Asian‐2. Dengue‐1–infected animals produced antibody with neutralizing titers of 2656 antibodies against dengue‐1, 409 against American‐2, and <20 against Asian‐2. Infection with American‐2 did not produce detectable viremia in either dengue‐1–immune or dengue‐1–naive animals. These findings support the hypothesis that dengue‐1 immunity might have prevented disease or altered the severity of disease in individuals sequentially infected with dengue‐1 and American‐2.
Received 15 April 2004; accepted 31 August 2004; electronically published 31 January 2005.
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Online publication date: 1-Aug-2008.
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Online publication date: 12-Mar-2008.
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Financial support: US Naval Medical Research Center (work unit 3002A 975 S B0202).
Presented in part: 52nd annual meeting of the American Society of Tropical Medicine and Hygiene, Philadelphia, Pennsylvania, 3–7 December 2003 (abstract 373).
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Present affiliations: US Naval Medical Research Center, Silver Spring, Maryland (T.J.K.); University of Texas Medical Branch, Galveston (D.M.W.); University of California, Los Angeles (A.S.G.); Naval Health Research Center, Department of Defense Center for Deployment Health Research, San Diego, California (K.L.R.).