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15 January 2005

Volume 191, Number 2
The Journal of Infectious Diseases 2005;191:159–163
© 2004 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2005/19102-0003$15.00
DOI: 10.1086/426826
BRIEF REPORT

Exhaustive Genotyping of the CEM15 (APOBEC3G) Gene and Absence of Association with AIDS Progression in a French Cohort

Hervé Do,1,3

Alexandre Vasilescu,3

Gora Diop,3

Thomas Hirtzig,3

Simon C. Heath,3

Cédric Coulonges,1

Jay Rappaport,4

Amu Therwath,1

Mark Lathrop,3

Fumihiko Matsuda,3 and

Jean‐François Zagury1,2,4

1Équipe Génomique, Bioinformatique et Pathologies du Système Immunitaire, INSERM EMI0355, and 2Chaire de Bioinformatique, Conservatoire National des Arts et Métiers, Paris, and 3Centre National de Génotypage, Evry, France; 4Center for Neurovirology, Temple University, Philadelphia, Pennsylvania

CEM15 (or APOBEC3G) has recently been identified as an inhibitor of human immunodeficiency virus type 1 (HIV‐1) replication in vitro. To evaluate the impact of its genetic variations on the progression of acquired immunodeficiency syndrome (AIDS), we have performed an extensive genetic analysis of CEM15. We have sequenced CEM15 in a cohort of 327 HIV‐1–seropositive patients with extreme disease progression phenotypes—either slow progression or rapid progression—and in 446 healthy control subjects, all of white descent. We have identified 29 polymorphisms with allele frequencies >1%, 14 of which were newly characterized. There were no significant associations between the polymorphisms or haplotypes of CEM15 and a disease progression phenotype in our cohort.

Received 12 May 2004; accepted 4 August 2004; electronically published 15 December 2004.

Reprints or correspondence: Dr. Jean‐François Zagury, Equipe Génomique, Bioinformatique et Pathologies du Système Immunitaire, INSERM EMI0355, 15 rue de l’Ecole de Médecine, 75006 Paris, France () or Fumihiko Matsuda, Centre National de Génotypage, 2 rue Gaston Crémieux, 91057 Evry Cedex, France ().

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Anurag Rathore, Animesh Chatterjee, Naohiko Yamamoto, Tapan N. Dhole. (2008) Absence of H186R Polymorphism in Exon 4 of the APOBEC3G Gene among North Indian Individuals . Genetic Testing 12:3, 453-456
Online publication date: 1-Oct-2008.
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Ajay Wanchu, Kumud K Singh. (2008) Function and polymorphisms of anti-HIV host factors: evidence from exposed uninfected individuals. Future HIV Therapy 2:2, 167-173
Online publication date: 1-Apr-2008.
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Welkin E Johnson. (2007) Host genetic variation and susceptibility to primate lentiviruses. Future HIV Therapy 1:4, 399-413
Online publication date: 1-Dec-2007.
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Vanessa B. Soros, Warner C. Greene. (2007) APOBEC3G and HIV-1: Strike and counterstrike. Current HIV/AIDS Reports 4:1, 3-9
Online publication date: 1-Mar-2007.
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Han Sang Valcke, Nicole F Bernard, Julie Bruneau, Michel Alary, Christos M Tsoukas, Michel Roger. (2006) APOBEC3G genetic variants and their association with risk of HIV infection in highly exposed Caucasians. AIDS 20:15, 1984???1986
Online publication date: 1-Nov-2006.
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Vanessa B. Soros, Warner C. Greene. (2006) APOBEC3G and HIV-1: Strike and counterstrike. Current Infectious Disease Reports 8:4, 317-323
Online publication date: 1-Sep-2006.
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Online publication date: 1-May-2006.
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Amalio Telenti and John P. A. Ioannidis. (2006) Susceptibility to HIV Infection—Disentangling Host Genetics and Host Behavior. The Journal of Infectious Diseases 193:1, 4-6
Online publication date: 1-Jan-2006.
Citation-Full Text-PDF Version (63 kB)
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Online publication date: 1-Nov-2005.
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David H Schwartz, Sujatha Iyengar. (2005) Toward genetic rationalization of antiretroviral therapy for HIV. AIDS 19:9, 975???977
Online publication date: 1-Jul-2005.
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  • Financial support: Agence Nationale de Recherche sur le SIDA, AIDS‐Cancer Vaccine Development Foundation, and Neovacs SA (grants to the Genetics of Resistance to Immunodeficiency Virus project); Ministère de la Recherche et des Nouvelles Technologies (support to the Centre National de Génotypage).

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