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1 January 2005

Volume 40, Number 1
Clinical Infectious Diseases 2005;40:38–45
© 2004 by the Infectious Diseases Society of America. All rights reserved.
1058-4838/2005/4001-0007$15.00
DOI: 10.1086/426438
MAJOR ARTICLE

Recommendations for the Selective Use of Herpes Simplex Virus Type 2 Serological Tests

Sarah L. Guerry,1,a

Heidi M. Bauer,1

Jeffrey D. Klausner,2

Barbara Branagan,3

Peter R. Kerndt,4

Barbara G. Allen,5 and

Gail Bolan1

1California Department of Health Services, Sexually Transmitted Disease Control Branch, Berkeley, 2San Francisco Department of Health, San Francisco, 3Sonoma County Department of Health, Santa Rosa, 4Los Angeles County Department of Health, Los Angeles, and 5Alameda County Public Health Department, Alameda, California

Background.Herpes simplex virus (HSV) type‐specific serological tests are now widely available, but indications for their use have not been well defined. The California Sexually Transmitted Diseases (STD) Controllers Association convened a committee of clinicians and researchers to make recommendations for the use of type‐specific HSV type 2 (HSV‐2) serological tests.

Methods.By means of a systematic review of the literature, evidence to support screening in selected high‐risk groups was compiled. Screening recommendations were developed by applying standard screening criteria to each specific population.

Results.The committee concluded that, in addition to serological testing for the diagnostic evaluation of patients with symptoms, screening of asymptomatic patients is likely to be beneficial among the following groups: those at high risk for STDs and human immunodeficiency virus (HIV) infection who are motivated to reduce their sexual risk behavior, HIV‐infected patients, and patients with sex partners with genital herpes. In contrast, universal screening for HSV‐2 infection in pregnant women is unlikely to be beneficial.

Conclusions.The targeted use of HSV‐2 serological tests for specific diagnostic situations and selected populations should benefit patients, providers, and the community. Until more data become available, these recommendations provide justification for selective diagnostic and screening uses of HSV‐2 serological tests.

Received 14 May 2004; accepted 23 August 2004; electronically published 6 December 2004.

Reprints or correspondence: Dr. Sarah L. Guerry, 2615 S. Grand Ave., STD Program, Rm. 500, Los Angeles, CA 90007 ().

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  • Present affiliation: Los Angeles County Department of Health, Los Angeles.

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