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1 December 2004

Volume 39, Number 11
Clinical Infectious Diseases 2004;39:1709–1712
© 2004 by the Infectious Diseases Society of America. All rights reserved.
1058-4838/2004/3911-0025$15.00
DOI: 10.1086/425742
HIV/AIDS BRIEF REPORT

Determinants of Immune Reconstitution Inflammatory Syndrome in HIV Type 1–Infected Patients with Tuberculosis after Initiation of Antiretroviral Therapy

Guillaume Breton,1

Xavier Duval,1,2

Candice Estellat,2

Xavier Poaletti,2

Daniel Bonnet,1

David Mvondo Mvondo,1

Pascale Longuet,1

Catherine Leport,1 and

Jean‐Louis Vildé1

Departments of 1Infectious and Tropical Diseases and 2Biostatistics and Epidemiology, INSERM E0357, Bichat‐Claude Bernard Hospital, Assistance Publique‐Hôpitaux de Paris, Paris, France

Immune reconstitution inflammatory syndrome (IRIS) occurred in 16 of 37 antiretroviral‐naive patients who were treated subsequently for tuberculosis and human immunodeficiency virus (HIV) type 1 infection. IRIS was related to increases in the CD4 cell percentage and in the ratio of CD4 cells to CD8 cells after 1 month of antiretroviral therapy and to dissemination of tuberculosis. These results have implications for the diagnosis of IRIS and the understanding of its pathogenesis.

Received 21 April 2004; accepted 29 July 2004; electronically published 9 November 2004.

Reprints or correspondence: Dr. Guillaume Breton, Service des Maladies Infectieuses et Tropicales, Hôpital Bichat‐Claude‐Bernard, 46, rue Henri Huchard, 75018 Paris, France ().

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