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1 February 2005 Supplement

Volume 191, Number S1
The Journal of Infectious Diseases 2005;191:S68–S77
© 2005 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2005/19103S1-0008$15.00
DOI: 10.1086/425269
SUPPLEMENT ARTICLE

Influence of Host Genetic Variation on Susceptibility to HIV Type 1 Infection

Richard A. Kaslow,1,2,3

Tevfik Dorak,1 and

James (Jianming) Tang2,3

Departments of 1Epidemiology, 2Medicine, and 3Microbiology, University of Alabama at Birmingham

For this review of genetic susceptibility to human immunodeficiency virus type 1 infection, far more information was available on factors involved in acquisition of the virus by an uninfected “recipient” than on propagation by the infected “donor.” Genetic variation presumably alters transmission from an infected host primarily by regulating the replication of virus and the concentration of particles circulating in blood and mucosal secretions of the potential donor. Thus, the effects of host genetic variation on transmission are inextricably bound to the well‐established and powerful effects on virus load at different stages of infection. Teasing apart the effects in both donors and recipients has been and will continue to be quite difficult.

Reprints or correspondence: Dr. Richard Kaslow, University of Alabama at Birmingham, 220 Ryals Bldg., 1665 University Blvd., Birmingham, AL 35294 ().

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  • Financial support: National Institutes of Health (grants AI41951‐05, AI40951, AI51173, and AI41530‐05).

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