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15 November 2004

Volume 190, Number 10
The Journal of Infectious Diseases 2004;190:1797–1803
© 2004 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2004/19010-0012$15.00
DOI: 10.1086/425017
MAJOR ARTICLE

Impaired T Helper 2 Response to Aeroallergen in Helminth‐Infected Patients with Asthma

Maria Ilma A. S. Araujo,1,4,5

Bradford Hoppe,6

Manoel Medeiros, Jr.,1

Leda Alcântara,2

Maria Cecília Almeida,1

Albert Schriefer,1

Ricardo R. Oliveira,1

Ramon Kruschewsky,4

Joanemile P. Figueiredo,1

Alvaro A. Cruz,3,5 and

Edgar M. Carvalho1,4,5

1Serviço de Imunologia, Hospital Universitario Professor Edgard Santos, 2Faculdade de Farmácia, and 3Centro de Enfermidades Respiratórias, Universidade Federal da Bahia, and 4Escola Bahiana de Medicina e Saúde Pública, and 5Instituto de Investigação em Imunologia (iii)/Conselho Nacional de Desenvolvimento Cientifico e Tecnológico, Salvador, Bahia, Brazil; 6Division of International Medicine and Infectious Diseases, Weill Medical College of Cornell University, New York, New York

Helminthic infections have been shown to inhibit allergy skin‐prick tests and to modify the course of asthma. We evaluated Dermatophagoides pteronyssinus–specific immune responses in patients with asthma by measuring levels of T helper 2 (Th2) cytokines in peripheral blood mononuclear cell (PBMC) cultures. PBMCs from Schistosoma mansoni–infected patients with asthma living in an area of polyhelminthic endemicity produced lower levels of interleukin (IL)–5 and IL‐4 in response to D. pteronyssinus antigen (Ag) 1 than did PBMCs from helminth‐free patients with asthma. In contrast, D. pteronyssinus Ag 1–specific production of IL‐10 was higher in helminth‐infected patients than in helminth‐free patients. The addition of recombinant human IL‐10 to D. pteronyssinus Ag 1–stimulated cultures of PBMCs from helminth‐free patients led to down‐modulation of production of IL‐5. After helminth‐infected patients with asthma received antihelminthic treatment, there was down‐modulation of D. pteronyssinus Ag 1–specific production of IL‐10 in vitro. S. mansoni–infected patients with asthma produce lower levels of Th2 cytokines than do helminth‐free patients with asthma, and this modulation is likely done by IL‐10.

Received 5 April 2004; accepted 28 May 2004; electronically published 12 October 2004.

Reprints or correspondence: Dr. Maria Ilma A. S. Araujo, Serviço de Imunologia, Hospital Universitario Professor Edgard Santos, Universidade Federal da Bahia, Rua João das Botas, s/n 5°, Andar, Canela, Salvador, Bahia, Brazil CEP 40110.160 ().

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  • Presented in part: XXVIII Meeting of the Brazilian Society of Immunology, Mangaratiba, Brazil, 2003 (poster 87); Quarto Congresso Latino‐Americano de Alergia e Imunologia em Pediatria, Foz do Iguaçu, Brazil, 2003 (abstract C19); 11th Annual International Health Medical Education Consortium Conference, Havana, Cuba, 2002 (poster 43); Sixth Annual Woods Hole Immunoparasitology Conference, Woods Hole, Massachusetts, 2002 (abstract 42); Mini Symposium 8: The Hygiene Hypothesis, Naples, Italy, 2002 (abstract 64).

    Financial support: National Institutes of Health (research grant D43 TW06216, funded by the Fogarty International Center and the National Heart Lung and Blood Institute); Fogarty Emerging Infectious Diseases (grant D43 TW00919); Fundação de Apoio à Pesquisa do Estado da Bahia.

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