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15 July 2004

Volume 39, Number 2
Clinical Infectious Diseases 2004;39:179–185
© 2004 by the Infectious Diseases Society of America. All rights reserved.
1058-4838/2004/3902-0006$15.00
DOI: 10.1086/421943
MAJOR ARTICLE

Pertussis‐Specific Cell‐Mediated and Humoral Immunity in Adolescents 3 Years after Booster Immunization with Acellular Pertussis Vaccine

Kati J. Edelman,1

Qiushui He,2

Johanna P. Makinen,2

Marjo S. Haanpera,2

Nhu Nguyen Tran Minh,2

Lode Schuerman,3

Joanne Wolter,3 and

Jussi A. Mertsola1

1Department of Pediatrics, Turku University Hospital, and 2Department of Human Microbial Ecology and Inflammation, National Public Health Institute, Turku, Finland; and 3GlaxoSmithKline Biologicals, Rixensart, Belgium

We evaluated pertussis‐specific cell‐mediated immunity (CMI) and humoral immunity in adolescents 3 years after they received an acellular pertussis booster immunization. Two hundred sixty‐four adolescents were examined for immunoglobulin G antibodies, and 49 were examined for CMI against Bordetella pertussis antigens 40 months after receiving the booster. A control group of similarly aged adolescents who had received diphtheria and tetanus vaccination 3 years earlier was included for comparison. Pertussis‐specific CMI persisted at greater than prebooster immunization levels. Although they had decreased by the 3‐year follow‐up, antibody levels remained significantly higher than prebooster immunization levels. Antibodies against pertussis antigens and CMI against filamentous hemagglutinin and pertactin were significantly higher in vaccinated adolescents than in control subjects. The acellular pertussis booster immunization provides long‐term CMI and humoral immunity lasting for 3 years. The significantly higher immunity observed in the diphtheria, tetanus, and acellular pertussis vaccine recipients, compared with that in control subjects, indicates that these responses are more likely to have resulted from the booster immunization than from the boosting effects of natural B. pertussis infection.

Received 17 October 2003; accepted 18 February 2004; electronically published 2 July 2004.

Reprints or correspondence: Dr. Kati Edelman, Dept. of Pediatrics, Turku University Hospital, Turku 20520, Finland ().

Cited by

M. Riffelmann, M. Littmann, C. Hülße, C. H. Wirsing von König. (2009) Antibody decay after immunisation of health-care workers with an acellular pertussis vaccine. European Journal of Clinical Microbiology & Infectious Diseases 28:3, 275-279
Online publication date: 1-Apr-2009.
CrossRef
G. GABUTTI, M. BERGAMINI, P. BONANNI, M. GUIDO, D. FENOGLIO, A. GIAMMANCO, L. SINDONI, C. ZOTTI, V. BODDI, F. BAMFI, R. SEVERINI, A. BECHINI, S. BOCCALINI, P. CROVARI. (2008) Assessment of humoral and cell-mediated immunity against Bordetella pertussis in adolescent, adult, and senior subjects in Italy. Epidemiology and Infection 136:11, 1576
Online publication date: 1-Dec-2008.
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Kati Edelman, Qiushui He, Johanna Mäkinen, Anna Sahlberg, Marjo Haanperä, Lode Schuerman, Joanne Wolter, and Jussi Mertsola. (2007) Immunity to Pertussis 5 Years after Booster Immunization during Adolescence. Clinical Infectious Diseases 44:10, 1271-1277
Online publication date: 15-May-2007.
Abstract-Full Text-PDF Version (292 kB)
Michael E Pichichero, Lisa M DeTora, David R Johnson. (2006) An adolescent and adult formulation combined tetanus, diphtheria and five-component pertussis vaccine. Expert Review of Vaccines 5:2, 175-187
Online publication date: 1-May-2006.
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David W. Scheifele, Scott A. Halperin, Jan J. Ochnio, Alexander C. Ferguson, Danuta M. Skowronski. (2006) A Modified Vaccine Reduces the Rate of Large Injection Site Reactions to the Preschool Booster Dose of Diphtheria-Tetanus-Acellular Pertussis Vaccine. The Pediatric Infectious Disease Journal 24:12, 1059-1066
Online publication date: 1-Jan-2006.
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Michael E. Pichichero, Janet R. Casey. (2005) Acellular Pertussis Vaccines for Adolescents. The Pediatric Infectious Disease Journal 24:Supplement, S117-S126
Online publication date: 1-Jul-2005.
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