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15 July 2004

Volume 39, Number 2
Clinical Infectious Diseases 2004;39:155–161
1058-4838/2004/3902-0001$15.00
DOI: 10.1086/421496
MAJOR ARTICLE

Mixed Cytomegalovirus Glycoprotein B Genotypes in Immunocompromised Patients

Alain Coaquette,

Alain Bourgeois,

Carine Dirand,

Audrey Varin,

Wan Chen, and

Georges Herbein

Department of Virology, Franche‐Comte University School of Medicine, Besançon, France

On the basis of sequence variation in the UL55 gene that encodes glycoprotein B (gB), human cytomegalovirus (CMV) can be classified into 4 gB genotypes. The goal of the present study was to determine the distribution of CMV gB genotypes and the effect of gB type on clinical outcomes in a cohort of immunocompromised patients, including both transplant recipients and nonrecipients. The distribution of gB genotypes was as follows: gB1, 28.9% of patients; gB2, 19.6%; gB3, 23.7%; gB4, 2.0%; and mixed infection, 25.8%. In contrast to patients infected with a single gB genotype, patients infected with multiple gB genotypes developed progression to CMV disease, had an increased rate of graft rejection, had higher CMV loads, and were significantly more often infected with other herpesviruses. The presence of multiple gB genotypes, rather than the presence of a single gB genotype, could be a critical factor associated with severe clinical manifestations in immunocompromised patients.

Received 19 December 2003; accepted 25 January 2004; electronically published 23 June 2004.

  • (See the editorial commentary by Crumpacker on pages 162–4)

Reprints or correspondence: Dr. Georges Herbein, Dept. of Virology, Franche‐Comte University School of Medicine, Hôpital Saint‐Jacques, 2, place Saint‐Jacques, F‐2 Besançon cedex, France ().

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