Linking Dynamical and Population Genetic Models of Persistent Viral Infection
1. Department of Ecology and Evolutionary Biology, University of Kansas, Lawrence, Kansas 66045‐7534;
2. Department of Microbiology, University of Kansas Medical Center, Kansas City, Kansas 66160‐7420;
3. Department of Zoology, P.O. Box 118525, University of Florida, Gainsville, Florida 32611‐8525
Abstract:
This article develops a theoretical framework to link dynamical and population genetic models of persistent viral infection. This linkage is useful because, while the dynamical and population genetic theories have developed independently, the biological processes they describe are completely interrelated. Parameters of the dynamical models are important determinants of evolutionary processes such as natural selection and genetic drift. We develop analytical methods, based on coupled differential equations and Markov chain theory, to predict the accumulation of genetic diversity within the viral population as a function of dynamical parameters. These methods are first applied to the standard model of viral dynamics and then generalized to consider the infection of multiple host cell types by the viral population. Each cell type is characterized by specific parameter values. Inclusion of multiple cell types increases the likelihood of persistent infection and can increase the amount of genetic diversity within the viral population. However, the overall rate of gene sequence evolution may actually be reduced.
Submitted July 22, 2002; Accepted December 18, 2002; Electronically published June 12, 2003
Keywords:
HIV, parasites, rapid evolution, viral dynamic.
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*Corresponding author; e‐mail: jkk@ku.edu.



