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1 February 2001

Volume 183, Number 3
The Journal of Infectious Diseases 2001;183:503–506
© 2001 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2001/18303-0019$02.00
DOI: 10.1086/318092
CONCISE COMMUNICATION

The HLA A2/6802 Supertype Is Associated with Reduced Risk of Perinatal Human Immunodeficiency Virus Type 1 Transmission

Kelly S. MacDonald,1,2

Joanne E. Embree,3

Nico J. D. Nagelkerke,5

Jose Castillo,2

Susie Ramhadin,3

Simon Njenga,4

Julius Oyug,4

Jekoniah Ndinya‐Achola,4

Brian H. Barber,1

Job J. Bwayo,4 and

Francis A. Plummer3,4

Departments of 1Immunology and 2Medicine, University of Toronto, and Department of Microbiology, Mount Sinai Hospital, Toronto, and 3Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada; 4Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya; 5National Institute of Public Health and the Environment, Bilthoven, and Department of Public Health, Erasmus University, Rotterdam, The Netherlands

Abstract

Certain HLAs may, in part, account for differences in human immunodeficiency virus type 1 (HIV‐1) susceptibility by presenting conserved immunogenic epitopes for T cell recognition. The HLA supertype A2/6802 is associated with decreased susceptibility to HIV‐1 among sex workers. The alleles in this supertype present the same HIV‐1 peptide epitopes for T cell recognition in some cases. This study sought to determine whether the HLA A2/6802 supertype influenced HIV‐1 transmission in a prospective cohort of HIV‐1–infected mothers and children in Kenya. Decreased perinatal HIV‐1 infection risk was strongly associated with possession of a functional cluster of related HLA alleles, called the A2/6802 supertype (odds ratio, 0.12; 95% confidence interval, 0.03–0.54; ). This effect was independent of the protective effect of maternal‐child HLA discordance. These data provide further evidence that HLA supertypes are associated with differential susceptibility to HIV‐1 transmission.

Received 12 September 2000; revised 24 October 2000; electronically published 11 December 2000.

Reprints or correspondence: Dr. Kelly S. MacDonald, Rm. 1484, Dept. of Microbiology, Mount Sinai Hospital, 600 University Ave., Toronto, Canada ().

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  • Presented in part: 12th World AIDS Conference, Geneva, Switzerland, June 1998 (abstract 210/31131).

    Study participants or their guardians provided informed consent for the study. This study was approved by the ethical review boards of the Universities of Nairobi and Manitoba.

    Financial support: Canadian Institutes of Health Research (CIHR; grant GR‐13301). K.S.M. is an Ontario HIV Treatment Network career scientist. F.A.P. is a CIHR senior scientist.

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