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June 2000

Volume 181, Number 6
The Journal of Infectious Diseases 2000;181:2011–2017
© 2000 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/2000/18106-0019$02.00
DOI: 10.1086/315487

Murine CD4+ T Lymphocyte Subsets and Host Defense against Pneumocystis carinii

Judd E. Shellito,1

Chandra Tate,1

Sanbao Ruan,1 and

Jay Kolls,1,2

1Section of Pulmonary and Critical Care Medicine, Department of Medicine, and 2Gene Therapy Program, Louisiana State University Health Sciences Center, New Orleans, Louisiana

The recruitment of specific subsets of CD4+ T lymphocytes to the lungs in response to Pneumocystis carinii was investigated. For mice inoculated with P. carinii, an ELISPOT assay was used to calculate the numbers of lymph node and lung tissue CD4+ cells that secreted interferon (IFN)–γ (Th1 cytokine) and interleukin (IL)–4 (Th2 cytokine) after concanavalin A stimulation. An ELISA was used to assay culture supernatants for cytokine concentrations. Precursor frequency of both IFN‐γ– and IL‐4–secreting cells was increased in lymph nodes at 1 week, whereas increases in Th1 and Th2 cells in lung tissue were delayed 3 weeks before declining. The frequency of IL‐4–secreting cells always was greater than the frequency of IFN‐γ secreting cells. These results demonstrate an early T lymphocyte response in draining lymph nodes, followed by later recruitment of Th1 and Th2 lymphocytes into lung tissue. The overall CD4+ T cell response to P. carinii involves both Th1 and Th2 subsets, but the response is Th2 dominant in both lymph node and lung tissue.

Received 7 January 2000; revised 6 March 2000; electronically published 31 May 2000.

Reprints or correspondence: Dr. Judd E. Shellito, Section of Pulmonary and Critical Care Medicine, Louisiana Health Sciences Center, 1901 Perdido St., Ste. 3205, New Orleans, LA 70112 ().

Cited by

Keigyou Yoh, Takehiko Sugawara, Hozumi Motohashi, Yousuke Takahama, Akio Koyama, Masayuki Yamamoto, Satoru Takahashi. (2002) Transgenic over-expression of MafK suppresses T cell proliferation and function in vivo. Genes to Cells 6:12, 1055-1066
Online publication date: 1-Jan-2002.
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Mingquan Zheng, Judd E. Shellito, Luis Marrero, Qiu Zhong, Stewart Julian, Peng Ye, Virginia Wallace, Paul Schwarzenberger, Jay K. Kolls. (2001) CD4+ T cell–independent vaccination against Pneumocystis carinii in mice. Journal of Clinical Investigation 108:10, 1469-1474
Online publication date: 15-Dec-2001.
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ANNALISA MACAGNO, CHIARA ATZORI, GIOVANNA FANTONI, ANTONELLA VALERIO, ANTONIETTA CARGNEL, MARCUS GROETTRUP. (2001) Pneumocystis carinii Does Not Induce Maturation of Human Dendritic Cells. The Journal of Eukaryotic Microbiology 48:s1, 167s-168s
Online publication date: 1-Jul-2001.
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  • Presented in part: annual meeting of the American Thoracic Society, San Diego, May 1999 (abstract A228).

    All animal procedures followed guidelines established by the Louisiana State University Health Sciences Center (LSUHSC) Institutional Animal Care and Use Committee.

    Grant support: National Institutes of Health (HL‐59724, AA‐08845); LSUHSC Alcohol Research Center.

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