All Journals > The Journal of Infectious Diseases > March 1999 > Granzyme B Expression during CMV Infection

Article Tools

Search for Related Articles

  • By Author
  • Search In

Announcements

Science Watch logo

JID Article Named "New Hot Paper" by ScienceWatch.com

Dr. Lauri Hicks' 2007 article on pneumococcal disease has been named a "hot new paper" by Thompson Reuters' ScienceWatch.com. Read a Q&A about the article with Dr. Hicks here. 

Press Release

Unique Collaboration Charts the Migrations of a Parasite that Affected History
Researchers Sequence Louse DNA from Mummies and Propose New Model for its Development


In the News

Featured in Grist
"Another symptom of swine flu: instant amnesia" May 11, 2009
Swine Influenza Virus: Zoonotic Potential and Vaccination Strategies for the Control of Avian and Swine Influenzas
Eileen Thacker and Bruce Janke
Read the veterinary literature on swine flu and you get a strong sense of what might be called vaccination treadmill: the hog industry is literally scrambling to generate new vaccines for the rapidly evolving flu strains that sweep through CAFOs. Writing in the Journal of Infectious Diseases [PDF] in 2008, Eileen Thacker and Bruce Janke of Iowa State University paint a stark picture: “A number of genetically diverse viruses are circulating in swine herds throughout the world and are a major cause of concern to the swine industry,” they write. “Influenza virus infections in swine and poultry are potential sources of viruses for the next pandemic among humans.”

Featured in New York Times
"Fear of a Swine Flu Epidemic in 1976 Offers Some Lessons, and Concerns, Today" May 8, 2009
Anti‐Ganglioside Antibody Induction by Swine (A/NJ/1976/H1N1) and Other Influenza Vaccines: Insights into Vaccine‐Associated Guillain‐Barré Syndrome
Irving Nachamkin, Sean V. Shadomy, Anthony P. Moran, Nancy Cox, Collette Fitzgerald, Huong Ung, Adrian T. Corcoran, John K. Iskander, Lawrence B. Schonberger, and Robert T. Chen
Irving Nachamkin, a professor of pathology and laboratory medicine at the University of Pennsylvania, examined some 1976 vaccine that had been saved by a scientist in Texas. In a paper published last year in The Journal of Infectious Diseases, he and colleagues reported that mice given the vaccine made antibodies that reacted with gangliosides, which are components of nerve cells. An antibody attack on gangliosides is part of the disease mechanism of Guillain-Barré.

Featured in AFP
"Swine flu vaccine 'could be ready soon'" May 7, 2009
A Broadly Protective Vaccine against Globally Dispersed Clade 1 and Clade 2 H5N1 Influenza Viruses
Mary A. Hoelscher, Neetu Singh, Sanjay Garg, Lakshmi Jayashankar, Vic Veguilla, Aseem Pandey, Yumi Matsuoka, Jacqueline M. Katz, Ruben Donis, Suresh K. Mittal, and Suryaprakash Sambhara
The vaccine Mittal created for the bird flu worked on three different strains isolated over a seven-year period and was described in papers for the Journal of Infectious Diseases and the journal Clinical Pharmacology and Therapeutics.

Featured in Newsweek
"The Path of a Pandemic" http://www.newsweek.com/id/195692
Swine Influenza Virus: Zoonotic Potential and Vaccination Strategies for the Control of Avian and Swine Influenzas
Eileen Thacker and Bruce Janke
Last year researchers from Iowa State University in Ames warned that pigs located in industrial-scale farms were being subjected to influenza infections from farm poultry, wild birds and their human handlers. Writing in The Journal of Infectious Diseases, Eileen Thacker and Bruce Janke said, "As a result of the constantly changing genetic makeup of individual influenza viruses in pigs, the U.S. swine industry is continually scrambling to respond to the influenza viruses circulating within individual production systems."

March 1999

Volume 179, Number 3
The Journal of Infectious Diseases 1999;179:693–696
© 1999 by the Infectious Diseases Society of America. All rights reserved.
0022-1899/99/7903-0022$02.00
DOI: 10.1086/314629
CONCISE COMMUNCIATIONS

Expression of Granzyme B during Primary Cytomegalovirus Infection after Renal Transplantation

Peter C. Wever,1

Liesbeth H. A. Spaeny,

Hans J. J. van der Vliet,

Rob J. Rentenaar,

Angela M. Wolbink,

Janto Surachno,

Pauline M. E. Wertheim,

Peter T. A. Schellekens,

C. Erik Hack, and

Ineke J. M. ten Berge

Renal Transplant Unit, Clinical and Laboratory Immunology Unit, Departments of Clinical Immunology and Rheumatology and of Clinical Virology, Academic Medical Center, University of Amsterdam; Central Laboratory of the Netherlands Red Cross Blood Transfusion Service and Laboratory for Clinical and Experimental Immunology, Department of Pathophysiology of Plasma Proteins, Amsterdam, The Netherlands

CD8+ T cells employ granzyme B (GrB) to induce apoptosis in target cells. Increased expression of GrB has been put forward as a diagnostic marker in transplant rejection and viral infection. Three‐color flow cytometric analysis revealed that peripheral blood CD8+ T lymphocytosis during primary cytomegalovirus infection after renal transplantation resulted from expansion of a CD8+GrB+CD62L+ T cell subset that was almost absent during stable transplant function or acute rejection. This expansion coincided with a temporary increase in systemic soluble GrB (sGrB) levels. No such increase was observed during stable transplant function or acute rejection. Thus, the primary immune response to cytomegalovirus infection is accompanied by appearance of CD8+GrB+CD62L+ T cells and increased sGrB levels in the peripheral blood compartment. Determination of the latter may provide a novel approach for monitoring viral infections.

Received 11 June 1998; revised 14 October 1998.

Reprints or correspondence: Dr. Ineke J. M. ten Berge, Academic Medical Center, University of Amsterdam, Dept. of Internal Medicine, Renal Transplant Unit F4‐215, P.O. Box 22700, 1100 DE Amsterdam, The Netherlands.

Cited by

B Kircher, P Schumacher, D Nachbaur. (2009) Granzymes A and B serum levels in allo-SCT. Bone Marrow Transplantation 43:10, 787-791
Online publication date: 1-Jun-2009.
CrossRef
Mahmoud Sadeghi, Volker Daniel, Cord Naujokat, Paul Schnitzler, Jan Schmidt, Arianeb Mehrabi, Martin Zeier, Gerhard Opelz. (2008) Dysregulated Cytokine Responses During Cytomegalovirus Infection in Renal Transplant Recipients. Transplantation 86:2, 275-285
Online publication date: 1-Aug-2008.
CrossRef
M. De Fost, W. Chierakul, R. Limpaiboon, A. Dondorp, N. J. White, T. Van Der Poll. (2007) Release of granzymes and chemokines in Thai patients with leptospirosis. Clinical Microbiology and Infection 13:4, 433-436
Online publication date: 1-May-2007.
CrossRef
Maria Yannaraki, Jean-Michel Rebibou, Didier Ducloux, Philippe Saas, Anne Duperrier, Sophie Felix, Gerard Rifle, Jean-Marc Chalopin, Patrick Herve, Pierre Tiberghien, Christophe Ferrand. (2006) Urinary cytotoxic molecular markers for a noninvasive diagnosis in acute renal transplant rejection*. Transplant International 19:9, 759-768
Online publication date: 1-Oct-2006.
CrossRef
Masayuki Nagasawa, Takeshi Isoda, Sukeyuki Itoh, Michiko Kajiwara, Tomohiro Morio, Norio Shimizu, Kazuyuki Ogawa, Kinya Nagata, Masataka Nakamura, Shuki Mizutani. (2006) Analysis of serum granulysin in patients with hematopoietic stem-cell transplantation: Its usefulness as a marker of graft-versus-host reaction. American Journal of Hematology 81:5, 340-348
Online publication date: 1-Jun-2006.
CrossRef
Ajda T. Rowshani, Merel C. M. Strik, Rosalie Molenaar, Si‐La Yong, Angela M. Wolbink, Frederike J. Bemelman, C. Erik Hack, and Ineke J. M. ten Berge. (2005) The Granzyme B Inhibitor SERPINB9 (Protease Inhibitor 9) Circulates in Blood and Increases on Primary Cytomegalovirus Infection after Renal Transplantation. The Journal of Infectious Diseases 192:11, 1908-1911
Online publication date: 1-Dec-2005.
Abstract-Full Text-PDF Version (281 kB)
Britta Bade, Jens Lohrmann, Anja ten Brinke, AngelaM. Wolbink, Gert-Jan Wolbink, InekeJ.M.ten Berge, J.Christian Virchow, Werner Luttmann, C.Erik Hack. (2005) Detection of soluble human granzymeKin vitro andin vivo. European Journal of Immunology 35:10, 2940-2948
Online publication date: 1-Nov-2005.
CrossRef
Adriana Weinberg, David A Wohl, Samantha MaWhinney, Rachel J Barrett, Darby G Brown, Nick Glomb, Charles van der Horst. (2003) Cytomegalovirus-specific IFN-?? production is associated with protection against cytomegalovirus reactivation in HIV-infected patients on highly active antiretroviral therapy. AIDS 17:17, 2445-2450
Online publication date: 1-Dec-2003.
CrossRef
Adriana Weinberg. (2002) The Role of Immune Reconstitution in Cytomegalovirus Infection. BioDrugs 16:2, 89-95
Online publication date: 1-Feb-2002.
CrossRef
Xavier Lafarge, Pierre Merville, Marie‐Cécile Cazin, Frank Bergé, Luc Potaux, Jean‐François Moreau, and Julie Déchanet‐Merville. (2001) Cytomegalovirus Infection in Transplant Recipients Resolves When Circulating γδ T Lymphocytes Expand, Suggesting a Protective Antiviral Role. The Journal of Infectious Diseases 184:5, 533-541
Online publication date: 1-Sep-2001.
Abstract-Full Text-PDF Version (223 kB)
Michael C. Bishop. (2001) Infections associated with dialysis and transplantation. Current Opinion in Urology 11:1, 67-73
Online publication date: 1-Feb-2001.
CrossRef
Fanny N. Lauw, Andrew J. H. Simpson, C. Erik Hack, Jan M. Prins, Angela M. Wolbink, Sander J. H. van Deventer, Wipada Chaowagul, Nicholas J. White, and Tom van der Poll. (2000) Soluble Granzymes Are Released during Human Endotoxemia and in Patients with Severe Infection Due to Gram‐Negative Bacteria. The Journal of Infectious Diseases 182:1, 206-213
Online publication date: 1-Jul-2000.
Abstract-Full Text-PDF Version (135 kB)
Rob J. Rentenaar, Laila E. Gamadia, Nicolette van derHoek, Frank N.J. van Diepen, René Boom, Jan F.L. Weel, Pauline M.E. Wertheim-van Dillen, René A.W. van Lier, Ineke J.M. ten Berge. (2000) Development of virus-specific CD4+ T cells during primary cytomegalovirus infection. Journal of Clinical Investigation 105:4, 541-548
Online publication date: 15-Mar-2000.
CrossRef

  • Presented in part: 4th International Symposium on Clinical Immunology, Amsterdam, June 1997; 13th European Immunology Meeting, Amsterdam, June 1997; 34th Congress of the EDTA‐ERA, Geneva, September 1997; 5th Basic Sciences Symposium, Chautauqua, New York, September 1997.

    Informed consent was obtained from all patients or their parents. The study was approved by the medical ethics review board, Academic Medical Center.

    Financial support: Dutch Kidney Foundation (grant C93.1278).

  • Present affiliation: Department of Medical Microbiology, Academic Medical Center, University of Amsterdam.

Back to Top
Close Popup