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June 2000

Volume 30, Number 6
Clinical Infectious Diseases 2000;30:843–850
© 2000 by the Infectious Diseases Society of America. All rights reserved.
1058-4838/2000/3006-0001$03.00
DOI: 10.1086/313812

Immunization against Potential Biological Warfare Agents

Theodore J. Cieslak,

George W. Christopher,

Mark G. Kortepeter,

John R. Rowe,

Julie A. Pavlin,

Randall C. Culpepper, and

Edward M. Eitzen, Jr.

From the Operational Medicine Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland

The intentional release of biological agents by belligerents or terrorists is a possibility that has recently attracted increased attention. Law enforcement agencies, military planners, public health officials, and clinicians are gaining an increasing awareness of this potential threat. From a military perspective, an important component of the protective pre‐exposure armamentarium against this threat is immunization. In addition, certain vaccines are an accepted component of postexposure prophylaxis against potential bioterrorist threat agents. These vaccines might, therefore, be used to respond to a terrorist attack against civilians. We review the development of vaccines against 10 of the most credible biological threats.

Received 12 July 1999; revised 30 December 1999; electronically published 20 June 2000.

Reprints or correspondence: Dr. Theodore J. Cieslak, Operational Medicine Division, USAMRIID, 1425 Porter St., Ft. Detrick, MD, 21702 ().

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Janice M. Rusnak, Mark G. Kortepeter, Robert J. Hawley, Ellen Boudreau, John Aldis, Phillip R. Pittman. (2004) Management Guidelines for Laboratory Exposures to Agents of Bioterrorism. Journal of Occupational and Environmental Medicine 46:8, 791-800
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Marcia A Firmani, Larry A Broussard. (2003) Molecular diagnostic techniques for use in response to bioterrorism. Expert Review of Molecular Diagnostics 3:5, 605-616
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Larry I Lutwick, Mary Beth Nierengarten. (2003) Vaccines for Category A bioterrorism diseases. Expert Opinion on Biological Therapy 2:8, 883-893
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Ronald A. Greenfield, Brock D. Lutz, Mark M. Huycke, Michael S. Gilmore. (2002) Unconventional Biological Threats and the Molecular Biological Response to Biological Threats. The American Journal of the Medical Sciences 323:6, 350-357
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Simona Bratu, Larry I Lutwick. (2002) Active immunisation against human tick-borne diseases. Expert Opinion on Biological Therapy 2:2, 187-195
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Renuka Heddurshetti, Wadchara Pumpradit, Larry I. Lutwick. (2001) Pulmonary manifestations of bioterrorism. Current Infectious Disease Reports 3:3, 249-257
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  • The opinions and assertions in this article are the private views of the authors and are not to be construed as official or as necessarily reflecting the views of the US Department of Defense, the US Army, or the US Army Medical Research Institute of Infectious Diseases.

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